PDF(Pubmed)
Abstract：
Cardiac dysfunction frequently emerges in the initial stages of cancer cachexia, posing a significant complication of the disease. Physical fitness is commonly recommended in these early stages of cancer cachexia due to its beneficial impacts on various aspects of the condition, including cardiac dysfunction. However, the direct functional impacts of exercise on the heart during cancer cachexia largely remain unexplored. In this study, we induced cancer cachexia in mice using a metastatic B16F10 melanoma model. Concurrently, these mice underwent a low-intensity exercise regimen to investigate its potential role in cardiac function during cachexia. Our findings indicate that exercise training can help prevent metastatic melanoma-induced muscle loss without significant alterations to body and fat weight. Moreover, exercise improved the melanoma-induced decline in left ventricular ejection fraction and fractional shortening, while also mitigating the increase in high-sensitive cardiac troponin T levels caused by metastatic melanoma in mice. Transcriptome analysis revealed that exercise significantly reversed the transcriptional alterations in the heart induced by melanoma, which were primarily enriched in pathways related to heart contraction. These results suggest that exercise can improve systolic heart function and directly influence the transcriptome of the heart during metastatic melanoma-induced cachexia.
摘要：
心脏功能障碍经常出现在癌症恶病质的初始阶段，构成了这种疾病的重大并发症。在癌症恶病质的这些早期阶段，通常建议身体健康，因为它对病情的各个方面都有有益的影响。包括心功能不全.然而,在癌症恶病质期间，运动对心脏的直接功能影响在很大程度上仍未被探索。在这项研究中,我们使用转移性B16F10黑色素瘤模型在小鼠中诱导癌症恶病质。同时,这些小鼠接受了低强度运动方案，以研究其在恶病质期间对心脏功能的潜在作用。我们的发现表明，运动训练可以帮助预防转移性黑色素瘤引起的肌肉损失，而不会显着改变体重和脂肪。此外，运动改善了黑色素瘤引起的左心室射血分数和缩短分数的下降，同时也减轻了小鼠转移性黑色素瘤引起的高敏心肌肌钙蛋白T水平的升高。转录组分析显示，运动显著逆转了黑素瘤诱导的心脏转录改变，主要富含与心脏收缩相关的途径。这些结果表明，运动可以改善心脏收缩功能，并在转移性黑色素瘤诱导的恶病质期间直接影响心脏的转录组。
