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Abstract：
Cognitive decline and spinal pain (back pain [BP] and neck pain [NP]) represent a major public health challenge, yet the potential relationship between them remains elusive. A retrospective analysis of the Longitudinal Study of Ageing Danish Twins was performed to determine any potential relationships between BP/NP and cognitive function adjusting for age, sex, educational and socioeconomic status. A total of 4731 adults (2788 females/1943 males) aged 78 ± 6 (SD) years were included in the analysis. We observed a 1-month prevalence of 25% with BP, 21% with NP and 11% for combined BP/NP. While there were no differences in cognition scores for males and females reporting combined BP/NP, compared to those without combined BP/NP (34.38 points [95% confidence interval (CI) = 31.88, 36.88] vs. 35.72 points [95% CI = 35.19, 36.26]; P = 0.180; and 35.72 points [95% CI = 35.19, 36.26] vs. 35.85 points [95% CI = 35.39, 36.31]; P = 0.327; for male and females, respectively), an adjusted analysis revealed that males with combined BP/NP presented with lower cognitive scores compared to males without combined BP/NP (81.26 points [95% CI = 73.80, 88.72] vs. 79.48 points [95% CI = 70.31, 88.66]; P = 0.043). The findings of this hypothesis-generating study may highlight a potential sex-specific association between spinal pain and later-life neurodegeneration.
摘要：
认知功能下降和脊柱疼痛（背痛[BP]和颈痛[NP]）是一项重大的公共卫生挑战，然而，他们之间的潜在关系仍然难以捉摸。对丹麦双胞胎的纵向研究进行了回顾性分析，以确定BP/NP与适应年龄的认知功能之间的任何潜在关系。性别,教育和社会经济地位。总共4731名78±6（SD）岁的成年人（2788名女性/1943名男性）被纳入分析。我们观察到BP的1个月患病率为25％，21%的NP和11%的联合BP/NP。虽然男性和女性合并BP/NP的认知评分没有差异，与没有合并BP/NP的那些相比(34.38点[95%置信区间(CI)=31.88，36.88]与35.72分[95%CI=35.19，36.26]；P=0.180；35.72分[95%CI=35.19，36.26]与35.85分[95％CI=35.39，36.31]；P=0.327；对于男性和女性，分别)，调整后的分析显示，与没有合并BP/NP的男性相比，合并BP/NP的男性认知得分较低（81.26分[95％CI=73.80，88.72]与79.48分[95%CI=70.31,88.66];P=0.043)。这项假设生成研究的结果可能强调了脊柱疼痛与晚年神经变性之间潜在的性别特异性关联。
