PDF(Pubmed)
Abstract：
The immune system classically consists of 2 lines of defense, innate and adaptive, both of which interact with one another effectively to protect us against any pathogenic threats. Importantly, there is a diverse subset of cells known as innate-like T cells that act as a bridge between the innate and adaptive immune systems and are pivotal players in eliciting inflammatory immune responses. A growing body of evidence has demonstrated the regulatory impact of these innate-like T cells in central nervous system (CNS) diseases and that such immune cells can traffic into the brain in multiple pathological conditions, which can be typically attributed to the breakdown of the blood-brain barrier. However, until now, it has been poorly understood whether innate-like T cells have direct protective or causative properties, particularly in CNS diseases. Therefore, in this review, our attention is focused on discussing the critical roles of 3 unique subsets of unconventional T cells, namely, natural killer T cells, γδ T cells, and mucosal-associated invariant T cells, in the context of CNS diseases, disorders, and injuries and how the interplay of these immune cells modulates CNS pathology, in an attempt to gain a better understanding of their complex functions.
摘要：
免疫系统通常由两道防线组成：先天和适应性，两者有效地相互作用，以保护我们免受任何致病威胁。重要的是,有一个被称为先天样T细胞的不同细胞亚群,它们是先天免疫系统和适应性免疫系统之间的桥梁,是引发炎症免疫反应的关键参与者.越来越多的证据表明，这些先天样T细胞在中枢神经系统（CNS）疾病中的调节作用，这种免疫细胞可以在多种病理条件下进入大脑，这通常可以归因于血脑屏障（BBB）的破坏。然而,直到现在,对于先天样T细胞是否具有直接的保护或致病特性，特别是中枢神经系统疾病。因此,在这次审查中,我们的注意力集中在讨论非常规T细胞的三个独特亚群的关键作用；即，自然杀伤T（NKT）细胞，γδT细胞和粘膜相关不变T（MAIT）细胞，在中枢神经系统疾病的背景下，疾病和损伤以及这些免疫细胞之间的相互作用如何调节CNS病理学，试图更好地理解它们的复杂功能。
