Abstract：
Polycyclic aromatic hydrocarbons (PAHs) have been reported to be associated with adverse pregnancy outcomes. However, there is limited knowledge regarding the effects of single or mixed PAHs exposure on unexplained recurrent spontaneous abortion (URSA). This study aimed to investigate the association between monohydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and URSA in a case-control study. The results showed that 1-NAP, 2-NAP, 9-FLU, and 1-PYR were detected in 100% of the subjects among measured all sixteen OH-PAHs. Compared with those in the lowest quartiles, participants in the highest quartiles of 3-BAA were associated with a higher risk of URSA (OR (95%CI) = 3.56(1.28-9.85)). With each one-unit increase of ln-transformed 3-BAA, the odds of URSA increased by 41% (OR (95%CI) = 1.41(1.05-1.89)). Other OH-PAHs showed negative or non-significant associations with URSA. Weighted quantile sum (WQS) regression, Bayesian kernel machine regression (BKMR), and quantile-based g-computation (qgcomp) analyses consistently identified 3-BAA as the major contributor to the mixture effect of OH-PAHs on URSA. Our findings suggest that exposure to 3-BAA may be a potential risk factor for URSA. However, further prospective studies are needed to validate our findings in the future.
摘要：
据报道，多环芳烃（PAHs）与不良妊娠结局有关。然而,关于单一或混合PAHs暴露对原因不明的复发性流产(URSA)的影响的知识有限.本研究旨在通过病例对照研究探讨单羟基多环芳烃（OH-PAHs）与URSA之间的关系。结果表明，1-NAP，2-NAP,9-FLU,在测量的所有16种OH-PAHs中，100％的受试者中检测到1-PYR。与最低四分位数相比，3-BAA最高四分位数的参与者与URSA的高风险相关(OR(95CI)=3.56(1.28~9.85)).随着ln转化的3-BAA每增加一个单位，URSA的几率增加了41%(OR(95CI)=1.41(1.05-1.89))。其他OH-PAHs与URSA呈负相关或不显着相关。加权分位数和(WQS)回归，贝叶斯核机回归(BKMR)，基于分位数的g计算（qgcomp）分析一致认为3-BAA是OH-PAHs对URSA的混合作用的主要贡献者。我们的研究结果表明，暴露于3-BAA可能是URSA的潜在危险因素。然而,未来还需要进一步的前瞻性研究来验证我们的发现.
