PDF(Pubmed)
Abstract：
The recurrence of Meniere disease (MD) strongly affects patient quality of life. Identifying the risk factors for MD is highly important for its prevention and treatment. Previous studies have suggested that alcohol intake may play a role in the development of MD. However, recent studies have shown that the causal relationship between alcohol consumption and MD remains controversial. In this paper, the Mendelian randomization (MR) method was used to determine the causal relationship between alcohol consumption usually consumed with meals and MD, with the aim of providing suggestions for alcohol intake management in individuals with MD and helping in the prevention and treatment of MD. Two-sample MR was used to investigate the causal relationship between alcohol usually taken with meals and MD. We used a dataset from a publicly available large-scale genome-wide association study (GWAS). Inverse variance weighting (IVW), MR-Egger, simple weighting, weighted weighting and the weighted median method were used for analysis. The final results showed that IVW (OR = 0.991, 95% CI: 0.983-0.998, P = .016) results suggested that there was statistical significance, but MR-Egger (OR = 0.978, 95% CI: 0.886-1.080, P = .679), weighted median methods (OR = 0.994, 95% CI: 0.985-1.004, P = .307) and Simple mode (OR = 0.995, 95% CI: 0.980-1.010, P = .566), Weighted mode (OR = 0.995, 95% CI: 0.981-1.010, P = .557) found no significant causal relationship. The results suggest that alcohol usually taken with meals may be negatively correlated with MD.
摘要：
梅尼埃病（MD）的复发强烈影响患者的生活质量。确定MD的危险因素对其预防和治疗非常重要。先前的研究表明，饮酒可能在MD的发展中起作用。然而,最近的研究表明，饮酒与MD之间的因果关系仍然存在争议。在本文中,孟德尔随机化（MR）方法用于确定通常与膳食一起饮酒与MD之间的因果关系，目的是为MD患者的酒精摄入管理提供建议，并帮助预防和治疗MD。使用两个样本的MR来研究通常随餐服用的酒精与MD之间的因果关系。我们使用了来自公开的大规模全基因组关联研究（GWAS）的数据集。方差反向加权(IVW)，MR-Egger,简单加权，采用加权加权加权和加权中位数法进行分析.最终结果显示IVW(OR=0.991,95%CI:0.983-0.998,P=0.016)结果提示有统计学意义,但MR-Egger（OR=0.978，95%CI：0.886-1.080，P=.679），加权中位数方法（OR=0.994，95%CI：0.985-1.004，P=.307）和简单模式（OR=0.995，95%CI：0.980-1.010，P=.566），加权模式(OR=0.995,95%CI:0.981-1.010,P=.557)未发现显著的因果关系。结果表明，通常随餐服用的酒精可能与MD呈负相关。
