Abstract：
UNASSIGNED: The clinical features of posterior cortical atrophy (PCA), a rare condition often caused by Alzheimer\'s disease, have been recently defined, while little is known about its neurophysiological correlates.
UNASSIGNED: To describe neurophysiological alterations of the visual pathway as assessed using visual field test (VF), visual evoked potentials (VEP), and electroretinogram (ERG) in PCA patients.
UNASSIGNED: Studies reporting VF, VEPs, and ERG in PCA patients were selected according PRISMA method. Of the 323 articles that emerged from the literature, 17 included the outcomes of interest. To these data, we added those derived from a patient cohort enrolled at our clinic.
UNASSIGNED: The literature review included 140 patients, half of them (50%) presented with homonymous hemianopia or quadrantanopia. VEPs were available in 4 patients (2 normal findings, 1 decreased amplitude, and 1 increased latency) and ERG in 3 patients (substantially normal findings). Our case series included 6 patients, presenting with homonymous lateral hemianopia in 50% and contralateral cortical atrophy. VEPs showed normal amplitude in 66-83% according to the stimulation check, and increased latency in 67% in absence of myelin damage on MRI. Latency was increased in both eyes in 50% and only on one side in the other 50%. Such alterations were observed in patients with more severe and symmetric atrophy. ERG showed normal findings.
UNASSIGNED: Neurophysiological investigations of the visual pathway in PCA are almost absent in literature. Alterations involve both amplitude and latency and can be also monocular. A multiple-point involvement of the optical pathway can be hypothesized.
UNASSIGNED: To describe neurophysiological alterations of the visual pathway as assessed using visual field test (VF), visual evoked potentials (VEP), and electroretinogram (ERG) in PCA patients.
UNASSIGNED: Studies reporting VF, VEPs, and ERG in PCA patients were selected according PRISMA method. Of the 323 articles that emerged from the literature, 17 included the outcomes of interest. To these data, we added those derived from a patient cohort enrolled at our clinic.
UNASSIGNED: The literature review included 140 patients, half of them (50%) presented with homonymous hemianopia or quadrantanopia. VEPs were available in 4 patients (2 normal findings, 1 decreased amplitude, and 1 increased latency) and ERG in 3 patients (substantially normal findings). Our case series included 6 patients, presenting with homonymous lateral hemianopia in 50% and contralateral cortical atrophy. VEPs showed normal amplitude in 66-83% according to the stimulation check, and increased latency in 67% in absence of myelin damage on MRI. Latency was increased in both eyes in 50% and only on one side in the other 50%. Such alterations were observed in patients with more severe and symmetric atrophy. ERG showed normal findings.
UNASSIGNED: Neurophysiological investigations of the visual pathway in PCA are almost absent in literature. Alterations involve both amplitude and latency and can be also monocular. A multiple-point involvement of the optical pathway can be hypothesized.
摘要：
■后皮质萎缩（PCA）的临床特征，通常由阿尔茨海默病引起的罕见疾病，最近被定义了，而对其神经生理学相关性知之甚少。
■为了描述使用视野测试（VF）评估的视觉通路的神经生理学改变，视觉诱发电位（VEP），PCA患者的视网膜电图（ERG）。
■报告VF的研究，VEP,根据PRISMA方法选择PCA患者的ERG和ERG。在文献中出现的323篇文章中，17包括感兴趣的结果。对于这些数据，我们添加了来自我们诊所纳入的患者队列的数据.
■文献综述包括140例患者，其中一半（50％）表现为同义偏盲或正交视。4例患者有VEP（2例正常检查结果，1振幅减小，和1增加的潜伏期）和3例患者的ERG（基本正常的结果）。我们的病例系列包括6名患者，表现为50％的同义侧偏盲和对侧皮质萎缩。根据刺激检查，VEP显示66-83％的正常振幅，在MRI上没有髓鞘损伤的情况下，潜伏期增加了67%。双眼的潜伏期增加了50％，仅一侧增加了其他50％。在更严重和对称性萎缩的患者中观察到了这种改变。ERG显示正常结果。
■关于PCA视觉通路的神经生理学研究在文献中几乎没有。改变涉及振幅和潜伏期,并且也可以是单眼的。可以假设光学路径的多点参与。
■为了描述使用视野测试（VF）评估的视觉通路的神经生理学改变，视觉诱发电位（VEP），PCA患者的视网膜电图（ERG）。
■报告VF的研究，VEP,根据PRISMA方法选择PCA患者的ERG和ERG。在文献中出现的323篇文章中，17包括感兴趣的结果。对于这些数据，我们添加了来自我们诊所纳入的患者队列的数据.
■文献综述包括140例患者，其中一半（50％）表现为同义偏盲或正交视。4例患者有VEP（2例正常检查结果，1振幅减小，和1增加的潜伏期）和3例患者的ERG（基本正常的结果）。我们的病例系列包括6名患者，表现为50％的同义侧偏盲和对侧皮质萎缩。根据刺激检查，VEP显示66-83％的正常振幅，在MRI上没有髓鞘损伤的情况下，潜伏期增加了67%。双眼的潜伏期增加了50％，仅一侧增加了其他50％。在更严重和对称性萎缩的患者中观察到了这种改变。ERG显示正常结果。
■关于PCA视觉通路的神经生理学研究在文献中几乎没有。改变涉及振幅和潜伏期,并且也可以是单眼的。可以假设光学路径的多点参与。
