Abstract：
BACKGROUND: Several research efforts have found that older schizophrenia patients are at higher risk for suicide. Related risk factors for suicide attempts in the elderly with schizophrenia are poorly understood. This study sought to assess the prevalence of suicide attempts and related risk variables in schizophrenia patients over the age of 50.
METHODS: We recruited 591 elderly patients over the age of 50. Demographic, clinical and blood parameters of all patients were collected. Patients with schizophrenia were evaluated for psychopathological symptoms using the Positive and Negative Syndrome Scale (PANSS).
RESULTS: The rate of suicide attempts among elderly Chinese schizophrenia patients was 15.2%. In these elderly schizophrenia patients, those who with suicide attempts had significantly higher scores for insomnia, depression and smoking addiction, and higher levels of red blood cells, Hc1 glycosylated hemoglobin and free T3, but significantly lower levels of hypersensitive C-reactive protein and -globulin. Binary logistic regression analysis showed that higher depression scores and smoking addiction were risk factors for suicide attempts in these patients. Additionally, multiple regression analyses showed that higher BMI and insomnia scores were associated with suicide risk scores in elderly schizophrenia patients.
CONCLUSIONS: Our research shows that there is a high incidence of suicide attempts in people over 50 years of age with schizophrenia. A number of clinically relevant factors and metabolic markers are associated with suicide attempts among elderly patients with schizophrenia.
METHODS: We recruited 591 elderly patients over the age of 50. Demographic, clinical and blood parameters of all patients were collected. Patients with schizophrenia were evaluated for psychopathological symptoms using the Positive and Negative Syndrome Scale (PANSS).
RESULTS: The rate of suicide attempts among elderly Chinese schizophrenia patients was 15.2%. In these elderly schizophrenia patients, those who with suicide attempts had significantly higher scores for insomnia, depression and smoking addiction, and higher levels of red blood cells, Hc1 glycosylated hemoglobin and free T3, but significantly lower levels of hypersensitive C-reactive protein and -globulin. Binary logistic regression analysis showed that higher depression scores and smoking addiction were risk factors for suicide attempts in these patients. Additionally, multiple regression analyses showed that higher BMI and insomnia scores were associated with suicide risk scores in elderly schizophrenia patients.
CONCLUSIONS: Our research shows that there is a high incidence of suicide attempts in people over 50 years of age with schizophrenia. A number of clinically relevant factors and metabolic markers are associated with suicide attempts among elderly patients with schizophrenia.
摘要：
背景：一些研究发现，老年精神分裂症患者自杀的风险更高。对老年精神分裂症患者自杀未遂的相关危险因素了解甚少。这项研究旨在评估50岁以上精神分裂症患者自杀企图的患病率和相关风险变量。
方法：我们招募了591名50岁以上的老年患者。人口统计,收集所有患者的临床和血液指标。使用阳性和阴性综合征量表（PANSS）评估精神分裂症患者的精神病理症状。
结果：中国老年精神分裂症患者的自杀未遂率为15.2%。在这些老年精神分裂症患者中，那些有自杀企图的人失眠得分明显更高，抑郁症和吸烟成瘾，和更高水平的红细胞，Hc1糖化血红蛋白和游离T3，但显着降低超敏C反应蛋白和-球蛋白的水平。二元logistic回归分析显示，抑郁评分较高和吸烟成瘾是这些患者自杀未遂的危险因素。此外,多元回归分析显示,在老年精神分裂症患者中,较高的BMI和失眠评分与自杀风险评分相关.
结论：我们的研究表明，在50岁以上的精神分裂症患者中，自杀未遂的发生率很高。许多临床相关因素和代谢标志物与老年精神分裂症患者的自杀企图有关。
方法：我们招募了591名50岁以上的老年患者。人口统计,收集所有患者的临床和血液指标。使用阳性和阴性综合征量表（PANSS）评估精神分裂症患者的精神病理症状。
结果：中国老年精神分裂症患者的自杀未遂率为15.2%。在这些老年精神分裂症患者中，那些有自杀企图的人失眠得分明显更高，抑郁症和吸烟成瘾，和更高水平的红细胞，Hc1糖化血红蛋白和游离T3，但显着降低超敏C反应蛋白和-球蛋白的水平。二元logistic回归分析显示，抑郁评分较高和吸烟成瘾是这些患者自杀未遂的危险因素。此外,多元回归分析显示,在老年精神分裂症患者中,较高的BMI和失眠评分与自杀风险评分相关.
结论：我们的研究表明，在50岁以上的精神分裂症患者中，自杀未遂的发生率很高。许多临床相关因素和代谢标志物与老年精神分裂症患者的自杀企图有关。
