PDF(Pubmed)
Abstract：
The epithelial barrier serves as a critical defense mechanism separating the human body from the external environment, fulfilling both physical and immune functions. This barrier plays a pivotal role in shielding the body from environmental risk factors such as allergens, pathogens, and pollutants. However, since the 19th century, the escalating threats posed by environmental pollution, global warming, heightened usage of industrial chemical products, and alterations in biodiversity have contributed to a noteworthy surge in allergic disease incidences. Notably, allergic diseases frequently exhibit dysfunction in the epithelial barrier. The proposed epithelial barrier hypothesis introduces a novel avenue for the prevention and treatment of allergic diseases. Despite increased attention to the role of barrier dysfunction in allergic disease development, numerous questions persist regarding the mechanisms underlying the disruption of normal barrier function. Consequently, this review aims to provide a comprehensive overview of the epithelial barrier\'s role in allergic diseases, encompassing influencing factors, assessment techniques, and repair methodologies. By doing so, it seeks to present innovative strategies for the prevention and treatment of allergic diseases.
摘要：
上皮屏障是将人体与外部环境分开的关键防御机制，同时实现身体和免疫功能。这种屏障在保护身体免受过敏原等环境风险因素的影响方面起着关键作用，病原体,和污染物。然而,自19世纪以来,环境污染带来的威胁不断升级，全球变暖,提高工业化学产品的使用率，生物多样性的改变导致了过敏性疾病发病率的显著上升。值得注意的是,过敏性疾病经常表现出上皮屏障的功能障碍。提出的上皮屏障假说为预防和治疗过敏性疾病提供了新的途径。尽管人们越来越关注屏障功能障碍在过敏性疾病发展中的作用，关于破坏正常屏障功能的潜在机制，仍然存在许多问题。因此,本综述旨在全面概述上皮屏障在过敏性疾病中的作用,包括影响因素，评估技术，和修复方法。通过这样做,它旨在提出预防和治疗过敏性疾病的创新策略。
