PDF(Pubmed)
Abstract：
Aromatase inhibitors (AIs) are a cornerstone adjuvant treatment of many hormone receptor-positive breast cancers, and nearly half of women taking aromatase inhibitors suffer from AI-induced arthralgia (AIA), also known as AI-associated musculoskeletal syndrome (AIMSS), for which there are limited evidence-based treatments. Pharmacologic management and complementary methods including supplements, exercise, physical therapy, yoga, acupuncture, and massage have all shown mixed results. Comprehensive diet and lifestyle strategies are understudied in AIA/AIMSS despite their disease-modifying effects across many chronic conditions. Here we report a case of a woman with stage 2 estrogen and progesterone receptor-positive invasive ductal carcinoma on adjuvant anastrozole whose AI-induced arthralgia was durably controlled through a Mediterranean plant-forward diet and daily physical activity guided by continuous glucose monitoring. We posit that diet and a lifestyle inclusive of daily physical activity constitute a low-cost, low-risk, and potentially high-reward strategy for controlling common AI-induced musculoskeletal symptoms and that more investigation in this arena, including well-designed randomized trials, is warranted.
摘要：
芳香化酶抑制剂（AIs）是许多激素受体阳性乳腺癌的基础辅助治疗，近一半服用芳香化酶抑制剂的女性患有AI诱发的关节痛（AIA），也称为AI相关肌肉骨骼综合征（AIMSS），基于证据的治疗方法有限。药物管理和补充方法，包括补充剂，锻炼,物理治疗,瑜伽,针灸,和按摩都显示出混合的结果。AIA/AIMSS对综合饮食和生活方式策略的研究不足，尽管它们在许多慢性疾病中具有改善疾病的作用。在这里，我们报告了一例2期雌激素和孕激素受体阳性的浸润性导管癌患者的阿那曲唑辅助治疗，其AI诱导的关节痛通过地中海植物向前饮食和连续葡萄糖监测指导的日常体力活动得到持久控制。我们认为饮食和包括日常体力活动在内的生活方式构成了一种低成本，低风险,以及控制常见AI引起的肌肉骨骼症状的潜在高回报策略，以及在这个领域进行更多调查，包括精心设计的随机试验，是有保证的。
