Abstract：
Our objective was to assess potassium monopersulfate as a disinfectant used in footbath to control digital dermatitis (DD) in dairy cows. We hypothesized that a potassium monopersulfate solution would control DD. A 180-day randomized negative controlled trial was conducted in a 265-Holstein free-stall facility. Throughout the trial, foot bathing was performed bi-weekly using a split (left vs. right feet) footbath: one tub filled with 1% potassium monopersulfate (treatment), the other with tap water (control). Digital dermatitis lesions were scored during trimming chute examinations of the unwashed hind heels every 90 days using the modified M-scoring system. Digital dermatitis lesions were re-categorized into four variables: 1) inactive; 2) active; 3) any; 4) inactive or absence of DD lesions. Three longitudinal outcomes were characterized: risks of 1) developing a DD lesion; 2) reactivating an inactive DD lesion; 3) development of an inactive or the absence of the DD lesion. A generalized linear model was used to compare the variables and longitudinal outcomes between treated and control groups. Prevalence of active DD lesions increased from 12.5% to 39.9% between days 0 and 90. This significant increase in prevalence justified the discontinuation of the study on day 90 for ethical reasons. There was no statistical difference between treated and control groups for the first outcome (RR: 1.0; 95% CI: 0.62, 1.7), the second outcome (RR: 1.0; 95% CI: 0.62,-1.7); or the third outcome (RR: 0.88; 95% CI: 0.37, 2.1). A 1% potassium monopersulfate footbath solution appears ineffective to control DD in this study.
摘要：
我们的目的是评估过氧硫酸钾作为用于足浴的消毒剂，以控制奶牛的数字皮炎（DD）。我们假设单过硫酸钾溶液可以控制DD。在265-Holstein免费摊位设施中进行了180天的随机阴性对照试验。在整个审判过程中,每两周使用一次分裂进行一次足浴(左与右脚）足浴：一个装满1％单过硫酸钾（治疗）的浴缸，另一个用自来水(对照)。在每90天使用改良的M评分系统对未清洗的后跟进行修剪斜槽检查时，对数字皮炎病变进行评分。指性皮炎病变被重新分类为四个变量：1）不活跃；2）活跃；3）任何；4）DD病变不活跃或不存在。表征了三个纵向结果：1）发生DD病变的风险；2）重新激活不活跃的DD病变；3）发展为不活跃或不存在DD病变。使用广义线性模型来比较治疗组和对照组之间的变量和纵向结果。在第0天和第90天之间，活动性DD病变的患病率从12.5％增加到39.9％。这种患病率的显着增加证明了出于伦理原因在第90天停止研究的理由。治疗组和对照组的第一个结果没有统计学差异（RR：1.0;95％CI：0.62,1.7），第二个结局(RR:1.0;95%CI:0.62,-1.7);或第三个结局(RR:0.88;95%CI:0.37,2.1)。在这项研究中，1％的过硫酸钾足浴溶液似乎对控制DD无效。
