PDF(Pubmed)
Abstract：
Fetal growth restriction (FGR) is one of the leading causes of perinatal morbidity and mortality. Many studies have reported an association between FGR and fetal Doppler indices focusing on umbilical artery (UA), middle cerebral artery (MCA), and ductus venosus (DV). The uteroplacental-fetal circulation which affects the fetal growth consists of not only UA, MCA, and DV, but also umbilical vein (UV), placenta and uterus itself. Nevertheless, there is a paucity of large-scale cohort studies that have assessed the association between UV, uterine wall, and placental thickness with perinatal outcomes in FGR, in conjunction with all components of the uteroplacental-fetal circulation. Therefore, this multicenter study will evaluate the association among UV absolute flow, placental thickness, and uterine wall thickness and adverse perinatal outcome in FGR fetuses. This multicenter retrospective cohort study will include singleton pregnant women who undergo at least one routine fetal ultrasound scan during routine antepartum care. Pregnant women with fetuses having structural or chromosomal abnormalities will be excluded. The U-AID indices (UtA, UA, MCA, and UV flow, placental and uterine wall thickness, and estimated fetal body weight) will be measured during each trimester of pregnancy. The study population will be divided into two groups: (1) FGR group (pregnant women with FGR fetuses) and (2) control group (those with normal growth fetus). We will assess the association between U-AID indices and adverse perinatal outcomes in the FGR group and the difference in U-AID indices between the two groups.
摘要：
胎儿生长受限（FGR）是围产期发病率和死亡率的主要原因之一。许多研究报道了FGR与胎儿多普勒指数之间的关联，重点是脐动脉（UA）。大脑中动脉(MCA),和静脉导管（DV）。影响胎儿生长的子宫胎盘-胎儿循环不仅包括UA，MCA,DV,还有脐静脉（UV），胎盘和子宫本身。然而，很少有大规模的队列研究评估紫外线之间的关联，子宫壁,胎盘厚度与围产期FGR结局，与子宫胎盘-胎儿循环的所有成分结合。因此,这项多中心研究将评估紫外线绝对流量之间的关联，胎盘厚度,FGR胎儿的子宫壁厚度和不良围产期结局。这项多中心回顾性队列研究将包括在常规产前护理期间接受至少一次常规胎儿超声扫描的单胎孕妇。胎儿结构或染色体异常的孕妇将被排除在外。U-AID指数(UtA，UA,MCA,和UV流，胎盘和子宫壁厚度，和估计的胎儿体重）将在怀孕的每个三个月期间进行测量。研究人群将分为两组：（1）FGR组（具有FGR胎儿的孕妇）和（2）对照组（具有正常生长胎儿的孕妇）。我们将评估FGR组中U-AID指数与不良围产期结局之间的关联以及两组之间U-AID指数的差异。
