Abstract：
Herbal medicines are widely perceived as natural and safe remedies. However, their concomitant use with prescribed drugs is a common practice, often undertaken without full awareness of the potential risks and frequently without medical supervision. This practice introduces a tangible risk of herb-drug interactions, which can manifest as a spectrum of consequences, ranging from acute, self-limited reactions to unpredictable and potentially lethal scenarios. This review offers a comprehensive overview of herb-drug interactions, with a specific focus on medications targeting the Central and Peripheral Nervous Systems. Our work draws upon a broad range of evidence, encompassing preclinical data, animal studies, and clinical case reports. We delve into the intricate pharmacodynamics and pharmacokinetics underpinning each interaction, elucidating the mechanisms through which these interactions occur. One pressing issue that emerges from this analysis is the need for updated guidelines and sustained pharmacovigilance efforts. The topic of herb-drug interactions often escapes the attention of both consumers and healthcare professionals. To ensure patient safety and informed decision-making, it is imperative that we address this knowledge gap and establish a framework for continued monitoring and education. In conclusion, the use of herbal remedies alongside conventional medications is a practice replete with potential hazards. This review not only underscores the real and significant risks associated with herb-drug interactions but also underscores the necessity for greater awareness, research, and vigilant oversight in this often-overlooked domain of healthcare.
摘要：
草药被广泛认为是自然和安全的补救措施。然而,他们与处方药同时使用是一种常见的做法，通常在没有充分意识到潜在风险的情况下进行，并且经常在没有医疗监督的情况下进行。这种做法引入了草药-药物相互作用的切实风险，这可以表现为一系列后果，从急性，对不可预测和潜在致命情况的自我限制反应。这篇综述提供了草药-药物相互作用的全面概述，特别关注针对中枢神经系统和周围神经系统的药物。我们的工作借鉴了广泛的证据，包括临床前数据，动物研究,和临床病例报告。我们深入研究了复杂的药效学和药代动力学，支持每种相互作用，阐明这些相互作用发生的机制。从这一分析中出现的一个紧迫问题是需要更新指南和持续的药物警戒工作。草药-药物相互作用的主题通常会引起消费者和医疗保健专业人员的注意。为了确保患者安全和明智的决策，我们必须解决这一知识差距，并建立一个持续监测和教育的框架。总之,与传统药物一起使用草药是一种充满潜在危险的做法。这篇综述不仅强调了与草药-药物相互作用相关的真实和重大风险，而且强调了提高意识的必要性。研究,在这个经常被忽视的医疗保健领域保持警惕。
