Abstract：
The transcription factor, known as basic leucine zipper ATF-like 3 (BATF3), is a crucial contributor to the development of conventional type 1 dendritic cells (cDC1), which is definitely required for priming CD8 + T cell-mediated immunity against intracellular pathogens and malignancies. In this respect, BATF3-dependent cDC1 can bring about immunological tolerance, an autoimmune response, graft immunity, and defense against infectious agents such as viruses, microbes, parasites, and fungi. Moreover, the important function of cDC1 in stimulating CD8 + T cells creates an excellent opportunity to develop a highly effective target for vaccination against intracellular pathogens and diseases. BATF3 has been clarified to control the development of CD8α+ and CD103+ DCs. The presence of BATF3-dependent cDC1 in the tumor microenvironment (TME) reinforces immunosurveillance and improves immunotherapy approaches, which can be beneficial for cancer immunotherapy. Additionally, BATF3 acts as a transcriptional inhibitor of Treg development by decreasing the expression of the transcription factor FOXP3. However, when overexpressed in CD8 + T cells, it can enhance their survival and facilitate their transition to a memory state. BATF3 induces Th9 cell differentiation by binding to the IL-9 promoter through a BATF3/IRF4 complex. One of the latest research findings is the oncogenic function of BATF3, which has been approved and illustrated in several biological processes of proliferation and invasion.
摘要：
转录因子，称为碱性亮氨酸拉链ATF样3（BATF3），是常规1型树突状细胞（cDC1）发展的关键因素，这对于引发CD8+T细胞介导的针对细胞内病原体和恶性肿瘤的免疫绝对是必需的。在这方面,依赖BATF3的cDC1可以带来免疫耐受，自身免疫反应，移植免疫，以及对病毒等传染因子的防御，微生物,寄生虫,和真菌。此外，cDC1在刺激CD8+T细胞中的重要功能为开发针对细胞内病原体和疾病的疫苗接种的高效靶标创造了极好的机会。已阐明BATF3可控制CD8α和CD103DCs的发展。肿瘤微环境（TME）中BATF3依赖性cDC1的存在增强了免疫监视并改善了免疫治疗方法，这对癌症免疫疗法是有益的。此外,BATF3通过降低转录因子FOXP3的表达而充当Treg发育的转录抑制剂。然而,当在CD8+T细胞中过度表达时，它可以增强他们的生存，并促进他们过渡到记忆状态。BATF3通过BATF3/IRF4复合物与IL-9启动子结合诱导Th9细胞分化。最新的研究发现之一是BATF3的致癌功能，它已被批准并在增殖和侵袭的多个生物学过程中得到说明。
