PDF(Pubmed)
Abstract：
Viruses, despite their simple structural composition, engage in intricate and complex interactions with their hosts due to their parasitic nature. A notable demonstration of viral behavior lies in their exploitation of lysosomes, specialized organelles responsible for the breakdown of biomolecules and clearance of foreign substances, to bolster their own replication. The man-nose-6-phosphate (M6P) pathway, crucial for facilitating the proper transport of hydrolases into lysosomes and promoting lysosome maturation, is frequently exploited for viral manipulation in support of replication. Recently, the discovery of lysosomal enzyme trafficking factor (LYSET) as a pivotal regulator within the lysosomal M6P pathway has introduced a fresh perspective on the intricate interplay between viral entry and host factors. This groundbreaking revelation illuminates unexplored dimensions of these interactions. In this review, we endeavor to provide a thorough overview of the M6P pathway and its intricate interplay with viral factors during infection. By consolidating the current understanding in this field, our objective is to establish a valuable reference for the development of antiviral drugs that selectively target the M6P pathway.
摘要：
病毒,尽管它们的结构组成简单，由于它们的寄生性质，它们与宿主进行错综复杂的相互作用。病毒行为的显着证明在于它们对溶酶体的利用，专门的细胞器负责生物分子的分解和外来物质的清除，来支持他们自己的复制。人鼻-6-磷酸（M6P）途径，对于促进水解酶正确运输到溶酶体和促进溶酶体成熟至关重要，经常被用于支持复制的病毒操作。最近,溶酶体酶运输因子（LYSET）作为溶酶体M6P途径中的关键调节因子的发现，为病毒进入与宿主因子之间的复杂相互作用提供了新的视角。这一开创性的启示阐明了这些互动的未探索的维度。在这次审查中,我们致力于全面概述M6P通路及其在感染过程中与病毒因子的复杂相互作用.通过巩固目前在这一领域的认识，我们的目标是为开发选择性靶向M6P通路的抗病毒药物提供有价值的参考。
