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Abstract：
There is a growing amount of evidence suggesting that immunity and inflammation play an important role in the pathophysiology of schizophrenia. In this study, we aimed to examine the relationship between hematological and inflammatory markers with symptom severity in Han Chinese patients with drug-free schizophrenia.
This retrospective study was conducted at Chaohu Hospital of Anhui Medical University and data were extracted from the electronic medical record system over a 5-year period (May 2017 to April 2022), including participants\' general and clinical information as well as Brief Psychiatric Rating Scale (BPRS) scores and hematological parameters.
A total of 2,899 patients with schizophrenia were identified through the initial search. After screening, 91 patients and 141 healthy controls (HCs) were included. The patients had a higher value of neutrophils/lymphocytes ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio (PLR) than HCs (all P < 0.001). MLR was positively correlated with BPRS total score (r = 0.337, P = 0.001) and resistance subscale score (r = 0.350, P = 0.001). Binary logistic regression analyses revealed that severely ill was significantly associated with being male and a higher value of MLR (Natural Logaruthm, Ln) (all P < 0.05), and the receiver operating characteristic (ROC) analysis showed good performance of a regression model with an area under the curve (AUC) value of 0.787.
Patients with drug-free schizophrenia have an unbalanced distribution of peripheral blood granulocytes, and elevated NLR, MLR and PLR. Patients with higher value of MLR tend to have more psychotic symptoms, especially those symptoms of hostility, uncooperativeness, and suspiciousness. Our study gives a preliminary indication that MLR is a potential predictor of disease severity in patients with drug-free schizophrenia.
This retrospective study was conducted at Chaohu Hospital of Anhui Medical University and data were extracted from the electronic medical record system over a 5-year period (May 2017 to April 2022), including participants\' general and clinical information as well as Brief Psychiatric Rating Scale (BPRS) scores and hematological parameters.
A total of 2,899 patients with schizophrenia were identified through the initial search. After screening, 91 patients and 141 healthy controls (HCs) were included. The patients had a higher value of neutrophils/lymphocytes ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio (PLR) than HCs (all P < 0.001). MLR was positively correlated with BPRS total score (r = 0.337, P = 0.001) and resistance subscale score (r = 0.350, P = 0.001). Binary logistic regression analyses revealed that severely ill was significantly associated with being male and a higher value of MLR (Natural Logaruthm, Ln) (all P < 0.05), and the receiver operating characteristic (ROC) analysis showed good performance of a regression model with an area under the curve (AUC) value of 0.787.
Patients with drug-free schizophrenia have an unbalanced distribution of peripheral blood granulocytes, and elevated NLR, MLR and PLR. Patients with higher value of MLR tend to have more psychotic symptoms, especially those symptoms of hostility, uncooperativeness, and suspiciousness. Our study gives a preliminary indication that MLR is a potential predictor of disease severity in patients with drug-free schizophrenia.
摘要：
■越来越多的证据表明免疫和炎症在精神分裂症的病理生理学中起重要作用。在这项研究中,我们旨在研究中国汉族无药精神分裂症患者的血液学和炎症标志物与症状严重程度之间的关系。
■这项回顾性研究是在安徽医科大学巢湖医院进行的，从电子病历系统中提取了5年的数据（2017年5月至2022年4月），包括参与者的一般和临床信息以及简明精神病评定量表（BPRS）评分和血液学参数。
■通过初步搜索确定了总共2899名精神分裂症患者。筛选后,包括91名患者和141名健康对照（HCs）。患者的中性粒细胞/淋巴细胞比值（NLR）值较高，单核细胞/淋巴细胞比率（MLR），和血小板/淋巴细胞比率（PLR）高于HC（均P<0.001）。MLR与BPRS总分(r=0.337,P=0.001)、阻力子量表评分(r=0.350,P=0.001)呈正相关。二元logistic回归分析显示，重病与男性和MLR值显着相关（自然Logaruthm，Ln)(均P<0.05),和接收器工作特性（ROC）分析显示回归模型的良好性能，曲线下面积（AUC）值为0.787。
■无药精神分裂症患者外周血粒细胞分布不平衡，和提升的NLR，MLR和PLR。MLR值越高的患者往往有更多的精神病性症状，尤其是那些敌意的症状，不合作，和可疑。我们的研究初步表明，MLR是无药精神分裂症患者疾病严重程度的潜在预测指标。
■这项回顾性研究是在安徽医科大学巢湖医院进行的，从电子病历系统中提取了5年的数据（2017年5月至2022年4月），包括参与者的一般和临床信息以及简明精神病评定量表（BPRS）评分和血液学参数。
■通过初步搜索确定了总共2899名精神分裂症患者。筛选后,包括91名患者和141名健康对照（HCs）。患者的中性粒细胞/淋巴细胞比值（NLR）值较高，单核细胞/淋巴细胞比率（MLR），和血小板/淋巴细胞比率（PLR）高于HC（均P<0.001）。MLR与BPRS总分(r=0.337,P=0.001)、阻力子量表评分(r=0.350,P=0.001)呈正相关。二元logistic回归分析显示，重病与男性和MLR值显着相关（自然Logaruthm，Ln)(均P<0.05),和接收器工作特性（ROC）分析显示回归模型的良好性能，曲线下面积（AUC）值为0.787。
■无药精神分裂症患者外周血粒细胞分布不平衡，和提升的NLR，MLR和PLR。MLR值越高的患者往往有更多的精神病性症状，尤其是那些敌意的症状，不合作，和可疑。我们的研究初步表明，MLR是无药精神分裂症患者疾病严重程度的潜在预测指标。
