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Abstract：
OBJECTIVE: Ocular melanoma is a rare, but deadly cancer. This large cancer registry study examines the associations between solar ultraviolet radiation (UVR) and incidence of different anatomical sites of ocular melanoma by sex, age, laterality, and race and ethnicity.
METHODS: Incidence data were derived from 21 cancer registries in the US for the years 2000-2019. Satellite-based UVR estimates were linked to county of residence at diagnosis. Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated for UVR quartiles using Poisson models.
RESULTS: UVR was not associated with total ocular melanoma (N = 18,089) comparing Q4 versus Q1 (IRR = 0.98; 95%CI:0.94,1.03; p-trend = 0.07) or conjunctival melanoma (IRR = 0.99; 95%CI:0.82,1.19; p-trend = 0.81). However, in analyses of continuous UVR (per 10 mW/m2), risks were reduced for total ocular melanoma (IRR = 0.97; 95% CI: 0.96, 0.99). Incidence was increased for ciliary body/iris melanoma in the highest UVR quartile (IRR = 1.63; 95%CI:1.43,1.87; p-trend < 0.0001) and remained increased in non-Hispanic White individuals only. Incidence was reduced for choroidal melanoma in the highest UVR quartile (IRR = 0.86; 95%CI:0.82,0.91; p-trend < 0.0001).
CONCLUSIONS: UVR may be associated with increased risk of ciliary body/iris melanoma. Reduced risk of choroidal melanoma may be due to higher diffuse UVR exposure to posterior ocular sites in locations at higher latitudes. Our results support and expand previous findings of associations of UVR using various surrogates on ocular melanoma risk and serve as a starting point for understanding the differences in the relationship between UVR and specific anatomical sites.
METHODS: Incidence data were derived from 21 cancer registries in the US for the years 2000-2019. Satellite-based UVR estimates were linked to county of residence at diagnosis. Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated for UVR quartiles using Poisson models.
RESULTS: UVR was not associated with total ocular melanoma (N = 18,089) comparing Q4 versus Q1 (IRR = 0.98; 95%CI:0.94,1.03; p-trend = 0.07) or conjunctival melanoma (IRR = 0.99; 95%CI:0.82,1.19; p-trend = 0.81). However, in analyses of continuous UVR (per 10 mW/m2), risks were reduced for total ocular melanoma (IRR = 0.97; 95% CI: 0.96, 0.99). Incidence was increased for ciliary body/iris melanoma in the highest UVR quartile (IRR = 1.63; 95%CI:1.43,1.87; p-trend < 0.0001) and remained increased in non-Hispanic White individuals only. Incidence was reduced for choroidal melanoma in the highest UVR quartile (IRR = 0.86; 95%CI:0.82,0.91; p-trend < 0.0001).
CONCLUSIONS: UVR may be associated with increased risk of ciliary body/iris melanoma. Reduced risk of choroidal melanoma may be due to higher diffuse UVR exposure to posterior ocular sites in locations at higher latitudes. Our results support and expand previous findings of associations of UVR using various surrogates on ocular melanoma risk and serve as a starting point for understanding the differences in the relationship between UVR and specific anatomical sites.
摘要：
目的：眼部黑色素瘤是一种罕见的，而是致命的癌症.这项大型癌症登记研究按性别检查了太阳紫外线辐射（UVR）与眼部黑色素瘤不同解剖部位发生率之间的关联。年龄,偏侧性,种族和民族。
方法：发病率数据来自2000-2019年美国21个癌症登记处。基于卫星的UVR估计与诊断时的居住地相关。使用泊松模型计算UVR四分位数的发生率比（IRRs）和95％置信区间（CIs）。
结果：UVR与总眼部黑色素瘤（N=18,089）相比，Q4与Q1（IRR=0.98；95CI：0.94,1.03；p趋势=0.07）或结膜黑色素瘤（IRR=0.99；95CI：0.82,1.19；p趋势=0.81）。然而,在连续UVR(每10mW/m2)分析中，全眼黑色素瘤的风险降低(IRR=0.97;95%CI:0.96,0.99).在最高的UVR四分位数中，睫状体/虹膜黑色素瘤的发病率增加（IRR=1.63;95CI：1.43,1.87;p趋势<0.0001），并且仅在非西班牙裔白人个体中仍然增加。最高UVR四分位数的脉络膜黑色素瘤发病率降低(IRR=0.86;95CI:0.82,0.91;p趋势<0.0001)。
结论：UVR可能与睫状体/虹膜黑色素瘤的风险增加有关。脉络膜黑素瘤的风险降低可能是由于较高的弥散性UVR暴露于高纬度位置的后眼部部位。我们的结果支持并扩展了使用各种替代剂对眼部黑色素瘤风险的UVR关联的先前发现，并作为理解UVR与特定解剖部位之间关系差异的起点。
方法：发病率数据来自2000-2019年美国21个癌症登记处。基于卫星的UVR估计与诊断时的居住地相关。使用泊松模型计算UVR四分位数的发生率比（IRRs）和95％置信区间（CIs）。
结果：UVR与总眼部黑色素瘤（N=18,089）相比，Q4与Q1（IRR=0.98；95CI：0.94,1.03；p趋势=0.07）或结膜黑色素瘤（IRR=0.99；95CI：0.82,1.19；p趋势=0.81）。然而,在连续UVR(每10mW/m2)分析中，全眼黑色素瘤的风险降低(IRR=0.97;95%CI:0.96,0.99).在最高的UVR四分位数中，睫状体/虹膜黑色素瘤的发病率增加（IRR=1.63;95CI：1.43,1.87;p趋势<0.0001），并且仅在非西班牙裔白人个体中仍然增加。最高UVR四分位数的脉络膜黑色素瘤发病率降低(IRR=0.86;95CI:0.82,0.91;p趋势<0.0001)。
结论：UVR可能与睫状体/虹膜黑色素瘤的风险增加有关。脉络膜黑素瘤的风险降低可能是由于较高的弥散性UVR暴露于高纬度位置的后眼部部位。我们的结果支持并扩展了使用各种替代剂对眼部黑色素瘤风险的UVR关联的先前发现，并作为理解UVR与特定解剖部位之间关系差异的起点。
