PDF(Pubmed)
Abstract：
BACKGROUND: Bullous pilomatricoma is a rare variant of pilomatricoma. As it has been published in sporadic case reports, a limited understanding of its clinicopathological characteristics restricts its effective diagnosis and treatment.
OBJECTIVE: This study aimed to analyze the clinicopathological and immunohistochemical characteristics of bullous pilomatricoma to better understand the bullous transformation of pilomatricoma.
METHODS: The authors conducted a retrospective study of 12 patients with bullous pilomatricoma and compared their clinical, histopathological, and immunohistochemical data with those of patients with ordinary pilomatricoma.
RESULTS: Bullous pilomatricoma showed no sex preference, with a mean onset age of 31.2 years. The common sites were the upper extremities and trunk. Bullous pilomatricoma had a shorter disease duration, a larger diameter, and a greater tendency to increase in size than those of ordinary pilomatricoma. Histopathologically, bullous pilomatricoma had a shorter duration, lesser calcification, more mitotic figures, and distinct dermal features from those of ordinary pilomatricoma. Immunohistochemically, the expression of Matrix Metalloprotease (MMP)-2, MMP-9, vascular endothelial growth factor receptor-3 (VEGFR-3), and VEGF-C was elevated.
CONCLUSIONS: The study was retrospective, and the sample size was small.
CONCLUSIONS: The distinctive features of bullous pilomatricoma potentially result from dermal changes associated with the release of angiogenic factors and proteolytic enzymes. This comprehensive analysis provides novel insights into the clinical features and pathogenesis of bullous pilomatricoma.
OBJECTIVE: This study aimed to analyze the clinicopathological and immunohistochemical characteristics of bullous pilomatricoma to better understand the bullous transformation of pilomatricoma.
METHODS: The authors conducted a retrospective study of 12 patients with bullous pilomatricoma and compared their clinical, histopathological, and immunohistochemical data with those of patients with ordinary pilomatricoma.
RESULTS: Bullous pilomatricoma showed no sex preference, with a mean onset age of 31.2 years. The common sites were the upper extremities and trunk. Bullous pilomatricoma had a shorter disease duration, a larger diameter, and a greater tendency to increase in size than those of ordinary pilomatricoma. Histopathologically, bullous pilomatricoma had a shorter duration, lesser calcification, more mitotic figures, and distinct dermal features from those of ordinary pilomatricoma. Immunohistochemically, the expression of Matrix Metalloprotease (MMP)-2, MMP-9, vascular endothelial growth factor receptor-3 (VEGFR-3), and VEGF-C was elevated.
CONCLUSIONS: The study was retrospective, and the sample size was small.
CONCLUSIONS: The distinctive features of bullous pilomatricoma potentially result from dermal changes associated with the release of angiogenic factors and proteolytic enzymes. This comprehensive analysis provides novel insights into the clinical features and pathogenesis of bullous pilomatricoma.
摘要：
背景：大疱性绒毛瘤是一种罕见的绒毛瘤变种。正如它已经在零星病例报告中公布的那样，对其临床病理特征的有限了解限制了其有效的诊断和治疗。
目的：本研究旨在分析大疱性毛囊瘤的临床病理和免疫组织化学特征，以更好地了解毛囊瘤的大疱性转化。
方法：作者对12例大疱性绒毛瘤患者进行了回顾性研究，并比较了他们的临床，组织病理学,以及普通绒毛瘤患者的免疫组织化学数据。
结果：大疱性绒毛瘤没有性别偏好，平均发病年龄为31.2岁。常见部位为上肢和躯干。大疱性毛囊瘤的病程较短，更大的直径，与普通的毛囊瘤相比，尺寸增加的趋势更大。组织病理学,大疱性毛囊瘤的持续时间较短，钙化较少,更多的有丝分裂图，与普通的毛囊瘤有明显的真皮特征。免疫组织化学，基质金属蛋白酶(MMP)-2、MMP-9、血管内皮生长因子受体-3(VEGFR-3)的表达,VEGF-C升高。
结论：这项研究是回顾性的，样本量很小。
结论：大疱性毛囊瘤的独特特征可能是由与血管生成因子和蛋白水解酶释放相关的真皮变化引起的。这种综合分析为大疱性毛囊瘤的临床特征和发病机理提供了新的见解。
目的：本研究旨在分析大疱性毛囊瘤的临床病理和免疫组织化学特征，以更好地了解毛囊瘤的大疱性转化。
方法：作者对12例大疱性绒毛瘤患者进行了回顾性研究，并比较了他们的临床，组织病理学,以及普通绒毛瘤患者的免疫组织化学数据。
结果：大疱性绒毛瘤没有性别偏好，平均发病年龄为31.2岁。常见部位为上肢和躯干。大疱性毛囊瘤的病程较短，更大的直径，与普通的毛囊瘤相比，尺寸增加的趋势更大。组织病理学,大疱性毛囊瘤的持续时间较短，钙化较少,更多的有丝分裂图，与普通的毛囊瘤有明显的真皮特征。免疫组织化学，基质金属蛋白酶(MMP)-2、MMP-9、血管内皮生长因子受体-3(VEGFR-3)的表达,VEGF-C升高。
结论：这项研究是回顾性的，样本量很小。
结论：大疱性毛囊瘤的独特特征可能是由与血管生成因子和蛋白水解酶释放相关的真皮变化引起的。这种综合分析为大疱性毛囊瘤的临床特征和发病机理提供了新的见解。
