Abstract：
UNASSIGNED: We reported imaging findings with complex signs that were corresponded with both dementia with Lewy bodies (DLB) and Alzheimer disease (AD) in the case of a 78-year-old woman. Initially suspected as DLB due to cognitive and movement issues, diagnostic support included the cingulate island sign on 18 F-FDG PET, positive 131 I-MIBG cardiac scintigraphy, and DAT PET. However, MRI indicated hippocampal atrophy, and 18 F-FDG PET showed hypometabolism in the medial temporal lobe, suggesting the possibility of concomitant AD. Subsequent detection of β-amyloid pathology and tau accumulation in the brain further supported the concurrent presence of AD pathology.
摘要：
■我们报道了在一名78岁女性的病例中，与路易体痴呆（DLB）和阿尔茨海默病（AD）相对应的复杂体征的影像学发现。由于认知和运动问题，最初被怀疑为DLB，诊断支持包括18F-FDGPET上的扣带回岛标志，131I-MIBG心脏闪烁显像阳性，和DATPET。然而,MRI提示海马萎缩，18F-FDGPET显示颞叶内侧代谢减退，提示合并AD的可能性。随后检测到脑中的β-淀粉样蛋白病理学和tau积累进一步支持AD病理学的同时存在。
