PDF(Pubmed)
Abstract：
Aeromonas species (spp.) are well-known fish pathogens, several of which have been recognized as emerging human pathogens. The organism is capable of causing a wide spectrum of diseases in humans, ranging from gastroenteritis, wound infections, and septicemia to devastating necrotizing fasciitis. The systemic form of infection is often fatal, particularly in patients with underlying chronic diseases. Indeed, recent trends demonstrate rising numbers of hospital-acquired Aeromonas infections, especially in immuno-compromised individuals. Additionally, Aeromonas-associated antibiotic resistance is an increasing challenge in combating both fish and human infections. The acquisition of antibiotic resistance is related to Aeromonas\' innate transformative properties including its ability to share plasmids and integron-related gene cassettes between species and with the environment. As a result, alternatives to antibiotic treatments are desperately needed. In that vein, many treatments have been proposed and studied extensively in the fish-farming industry, including treatments that target Aeromonas quorum sensing. In this review, we discuss current strategies targeting quorum sensing inhibition and propose that such studies empower the development of novel chemotherapeutic approaches to combat drug-resistant Aeromonas spp. infections in humans. KEY POINTS: • Aeromonas notoriously acquires and maintains antimicrobial resistance, making treatment options limited. • Quorum sensing is an essential virulence mechanism in Aeromonas infections. • Inhibiting quorum sensing can be an effective strategy in combating Aeromonas infections in animals and humans.
摘要：
气单胞菌物种（spp。)是众所周知的鱼类病原体，其中一些已被认为是新兴的人类病原体。这种生物能够在人类中引起广泛的疾病，从肠胃炎，伤口感染,败血症和破坏性坏死性筋膜炎。全身形式的感染通常是致命的，特别是患有潜在慢性病的患者。的确,最近的趋势表明，医院获得性气单胞菌感染的数量不断增加，尤其是在免疫受损的个体中。此外,与气单胞菌相关的抗生素耐药性在对抗鱼类和人类感染方面是一个日益严峻的挑战。抗生素耐药性的获得与气单胞菌的先天转化特性有关，包括其在物种之间以及与环境共享质粒和整合子相关基因盒的能力。因此,迫切需要替代抗生素治疗。在这种情况下，在养鱼业中已经提出了许多治疗方法并进行了广泛的研究，包括针对气单胞菌群体感应的治疗。在这次审查中,我们讨论了针对群体感应抑制的当前策略，并建议此类研究能够开发新的化疗方法来对抗耐药的气单胞菌。人类感染。关键点：•众所周知，气单胞菌获得并保持耐药性，使治疗选择有限。•群体感应是气单胞菌感染中必不可少的毒力机制。•抑制群体感应可以是对抗动物和人类中的气单胞菌感染的有效策略。
