PDF(Pubmed)
Abstract：
Autoimmune thyroid disease (AITD) is the main cause of hypothyroidism in women of childbearing age. Bisphenol A (BPA) is an environmental factor affecting AITD. This study aims to investigate relationship between BPA and AITD in women of childbearing age, thereby contributing novel evidence for the prevention of hypothyroidism in this specific demographic.
A total of 155 women of childbearing age were enrolled in this study, including the euthyroid group comprised 60 women with euthyroidism and thyroid autoantibodies negativity and the AITD group consisted of 95 women with euthyroidism and at least one thyroid autoantibody positivity. The general information, thyroid function, thyroid autoantibodies, and thyroid ultrasound results of the two groups of women of childbearing age were recorded. Urinary BPA and urinary BPA/creatinine were detected. The difference of BPA levels between the two groups was compared. logistic regression was used to analyze the correlation between BPA and AITD.
The proportion of multiparous and serum thyroid stimulating hormone levels were significantly higher in the AITD group compared to the euthyroid group. Logistic regression analysis revealed that BPA levels did not exhibit a statistically significant association with AITD. Spearman correlation analysis revealed a statistically significant correlation between BPA and urinary iodine levels (r=0.30, P < 0.05), as well as a correlation between urinary BPA and free tetraiodothyronine (FT4) levels (r=0.29, P < 0.05).
This study revealed a correlation between urinary BPA levels and FT4 levels. However, it did not establish a relationship between BPA and AITD in women of childbearing age.
A total of 155 women of childbearing age were enrolled in this study, including the euthyroid group comprised 60 women with euthyroidism and thyroid autoantibodies negativity and the AITD group consisted of 95 women with euthyroidism and at least one thyroid autoantibody positivity. The general information, thyroid function, thyroid autoantibodies, and thyroid ultrasound results of the two groups of women of childbearing age were recorded. Urinary BPA and urinary BPA/creatinine were detected. The difference of BPA levels between the two groups was compared. logistic regression was used to analyze the correlation between BPA and AITD.
The proportion of multiparous and serum thyroid stimulating hormone levels were significantly higher in the AITD group compared to the euthyroid group. Logistic regression analysis revealed that BPA levels did not exhibit a statistically significant association with AITD. Spearman correlation analysis revealed a statistically significant correlation between BPA and urinary iodine levels (r=0.30, P < 0.05), as well as a correlation between urinary BPA and free tetraiodothyronine (FT4) levels (r=0.29, P < 0.05).
This study revealed a correlation between urinary BPA levels and FT4 levels. However, it did not establish a relationship between BPA and AITD in women of childbearing age.
摘要：
■自身免疫性甲状腺疾病（AITD）是育龄妇女甲状腺功能减退的主要原因。双酚A(BPA)是影响AITD的环境因素。本研究旨在探讨育龄妇女BPA与AITD的关系。从而为预防这种特定人群中的甲状腺功能减退症提供了新的证据。
■本研究共纳入155名育龄妇女，甲状腺功能正常组包括60例甲状腺功能正常且甲状腺自身抗体阴性的女性,AITD组包括95例甲状腺功能正常且至少1例甲状腺自身抗体阳性的女性.一般资料,甲状腺功能,甲状腺自身抗体，并记录两组育龄妇女的甲状腺超声检查结果。检测尿BPA和尿BPA/肌酐。比较两组间BPA水平的差异。采用logistic回归分析BPA与AITD的相关性。
■与甲状腺功能正常组相比，AITD组的多胎和血清促甲状腺激素水平的比例明显更高。Logistic回归分析显示，BPA水平与AITD无统计学意义。Spearman相关分析显示,双酚A与尿碘水平呈显著相关(r=0.30,P<0.05)。以及尿BPA与游离四碘甲状腺原氨酸（FT4）水平之间的相关性（r=0.29，P<0.05）。
■这项研究揭示了尿BPA水平与FT4水平之间的相关性。然而,在育龄妇女中，它没有建立BPA和AITD之间的关系。
■本研究共纳入155名育龄妇女，甲状腺功能正常组包括60例甲状腺功能正常且甲状腺自身抗体阴性的女性,AITD组包括95例甲状腺功能正常且至少1例甲状腺自身抗体阳性的女性.一般资料,甲状腺功能,甲状腺自身抗体，并记录两组育龄妇女的甲状腺超声检查结果。检测尿BPA和尿BPA/肌酐。比较两组间BPA水平的差异。采用logistic回归分析BPA与AITD的相关性。
■与甲状腺功能正常组相比，AITD组的多胎和血清促甲状腺激素水平的比例明显更高。Logistic回归分析显示，BPA水平与AITD无统计学意义。Spearman相关分析显示,双酚A与尿碘水平呈显著相关(r=0.30,P<0.05)。以及尿BPA与游离四碘甲状腺原氨酸（FT4）水平之间的相关性（r=0.29，P<0.05）。
■这项研究揭示了尿BPA水平与FT4水平之间的相关性。然而,在育龄妇女中，它没有建立BPA和AITD之间的关系。
