Abstract：
Delaying childbearing age has become a trend in modern times, but it has also led to a common challenge in clinical reproductive medicine-diminished ovarian reserve (DOR). Since the mechanism behind DOR is unknown and its clinical features are complex, physicians find it difficult to provide targeted treatment. Many factors affect ovarian reserve function, and existing studies have shown that genetic variants, upstream regulatory genes, and changes in protein expression levels are present in populations with reduced ovarian reserve function. However, existing therapeutic regimens often do not target the genetic profile for more individualized treatment. In this paper, we review the types of genetic variants, mutations, altered expression levels of microRNAs, and other related factors and their effects on the regulation of follicular development, as well as altered DNA methylation. We hope this review will have significant implications for the future treatment of individuals with reduced ovarian reserve.
摘要：
推迟生育年龄已经成为现代的一种趋势,但它也导致了临床生殖医学的共同挑战-卵巢储备减少(DOR).由于DOR背后的机制未知且其临床特征复杂，医生发现很难提供有针对性的治疗。影响卵巢储备功能的因素很多,现有的研究表明，遗传变异，上游调控基因，在卵巢储备功能降低的人群中存在蛋白质表达水平的变化。然而,现有的治疗方案通常不针对遗传特征进行更个性化的治疗.在本文中,我们回顾了遗传变异的类型，突变,改变microRNAs的表达水平，和其他相关因素及其对卵泡发育的调控作用，以及改变的DNA甲基化。我们希望这篇综述将对未来卵巢储备减少的个体的治疗具有重要意义。
