PDF(Pubmed)
Abstract：
OBJECTIVE: Motor neuron disease (MND) is a neurodegenerative disease, progressively impacting function and self-perceived quality of life (QoL). Up to 50% of people with MND can present with cognitive and behavioural impairment, with an associated increase in caregiver burden or strain. However, there has been no systematic exploration of the relationship between QoL and cognitive or behavioural impairment in MND. The aim was to determine if there is a relationship between QoL and cognitive/behavioural impairment in MND, while also supplementarily looking to determine the types of cognitive/behavioural and QoL measures utilised in these studies.
METHODS: A systematic search was performed across multiple databases (PsychINFO, Embase, Medline, AMED) for research published up to the date of February 22, 2023. Studies utilising quantitative methods of measuring QoL, cognitive/behavioural functioning/impairment were included. Findings examining relationships between QoL-cognitive/behavioural impairment were extracted and synthesised.
RESULTS: A total of 488 studies were identified, with 14 studies included in the systematic review. All 14 studies were observational (11 cross-sectional, 3 longitudinal). 13 studies utilised MND non-specific measures, particularly in relation to QoL and cognitive impairment. Of 8 studies measuring behavioural impairment 62.5% (N = 5) found either a lower QoL difference or association. Only 33.3% (N = 4) of 12 studies measuring cognitive impairment found a lower QoL difference or association.
CONCLUSIONS: This systematic review shows that behavioural impairment may have an impact on QoL in MND. There is variability in types of assessments used to measure QoL and also cognitive/behavioural impairment, most of which are disease-non-specific. Recommendations for future research are to use comprehensive disease-specific, multidomain measures to further elucidate the QoL-cognitive/behavioural impairment relationship.
METHODS: A systematic search was performed across multiple databases (PsychINFO, Embase, Medline, AMED) for research published up to the date of February 22, 2023. Studies utilising quantitative methods of measuring QoL, cognitive/behavioural functioning/impairment were included. Findings examining relationships between QoL-cognitive/behavioural impairment were extracted and synthesised.
RESULTS: A total of 488 studies were identified, with 14 studies included in the systematic review. All 14 studies were observational (11 cross-sectional, 3 longitudinal). 13 studies utilised MND non-specific measures, particularly in relation to QoL and cognitive impairment. Of 8 studies measuring behavioural impairment 62.5% (N = 5) found either a lower QoL difference or association. Only 33.3% (N = 4) of 12 studies measuring cognitive impairment found a lower QoL difference or association.
CONCLUSIONS: This systematic review shows that behavioural impairment may have an impact on QoL in MND. There is variability in types of assessments used to measure QoL and also cognitive/behavioural impairment, most of which are disease-non-specific. Recommendations for future research are to use comprehensive disease-specific, multidomain measures to further elucidate the QoL-cognitive/behavioural impairment relationship.
摘要：
目的：运动神经元病（MND）是一种神经退行性疾病，逐步影响功能和自我感知的生活质量(QoL)。高达50%的MND患者会出现认知和行为障碍，与相关的增加照顾者的负担或紧张。然而,对于MND中QoL与认知或行为障碍之间的关系尚未有系统的研究.目的是确定在MND中QoL与认知/行为障碍之间是否存在关系，同时补充寻找确定这些研究中使用的认知/行为和QoL测量的类型。
方法：在多个数据库中进行了系统搜索(PsychINFO，Embase,Medline,AMED）为截至2023年2月22日发表的研究。利用定量方法测量QoL的研究，包括认知/行为功能/损害.提取并综合了检查QoL-认知/行为损害之间关系的结果。
结果：共确定了488项研究，14项研究纳入系统评价。所有14项研究均为观察性研究(11项横断面研究，3纵向)。13项研究使用了MND非特异性措施，特别是与QoL和认知障碍有关。在8项测量行为障碍的研究中，62.5%(N=5)发现QoL差异或相关性较低。在测量认知障碍的12项研究中，只有33.3％（N=4）发现较低的QoL差异或相关性。
结论：本系统评价显示行为损害可能对MND患者的生活质量有影响。用于测量QoL和认知/行为损害的评估类型存在差异，其中大多数是非特异性疾病。未来研究的建议是使用全面的疾病特异性，多领域措施，以进一步阐明QoL-认知/行为损害关系。
方法：在多个数据库中进行了系统搜索(PsychINFO，Embase,Medline,AMED）为截至2023年2月22日发表的研究。利用定量方法测量QoL的研究，包括认知/行为功能/损害.提取并综合了检查QoL-认知/行为损害之间关系的结果。
结果：共确定了488项研究，14项研究纳入系统评价。所有14项研究均为观察性研究(11项横断面研究，3纵向)。13项研究使用了MND非特异性措施，特别是与QoL和认知障碍有关。在8项测量行为障碍的研究中，62.5%(N=5)发现QoL差异或相关性较低。在测量认知障碍的12项研究中，只有33.3％（N=4）发现较低的QoL差异或相关性。
结论：本系统评价显示行为损害可能对MND患者的生活质量有影响。用于测量QoL和认知/行为损害的评估类型存在差异，其中大多数是非特异性疾病。未来研究的建议是使用全面的疾病特异性，多领域措施，以进一步阐明QoL-认知/行为损害关系。
