METHODS: A systematic search was performed across multiple databases (PsychINFO, Embase, Medline, AMED) for research published up to the date of February 22, 2023. Studies utilising quantitative methods of measuring QoL, cognitive/behavioural functioning/impairment were included. Findings examining relationships between QoL-cognitive/behavioural impairment were extracted and synthesised.
RESULTS: A total of 488 studies were identified, with 14 studies included in the systematic review. All 14 studies were observational (11 cross-sectional, 3 longitudinal). 13 studies utilised MND non-specific measures, particularly in relation to QoL and cognitive impairment. Of 8 studies measuring behavioural impairment 62.5% (N = 5) found either a lower QoL difference or association. Only 33.3% (N = 4) of 12 studies measuring cognitive impairment found a lower QoL difference or association.
CONCLUSIONS: This systematic review shows that behavioural impairment may have an impact on QoL in MND. There is variability in types of assessments used to measure QoL and also cognitive/behavioural impairment, most of which are disease-non-specific. Recommendations for future research are to use comprehensive disease-specific, multidomain measures to further elucidate the QoL-cognitive/behavioural impairment relationship.
方法:在多个数据库中进行了系统搜索(PsychINFO,Embase,Medline,AMED)为截至2023年2月22日发表的研究。利用定量方法测量QoL的研究,包括认知/行为功能/损害.提取并综合了检查QoL-认知/行为损害之间关系的结果。
结果:共确定了488项研究,14项研究纳入系统评价。所有14项研究均为观察性研究(11项横断面研究,3纵向)。13项研究使用了MND非特异性措施,特别是与QoL和认知障碍有关。在8项测量行为障碍的研究中,62.5%(N=5)发现QoL差异或相关性较低。在测量认知障碍的12项研究中,只有33.3%(N=4)发现较低的QoL差异或相关性。
结论:本系统评价显示行为损害可能对MND患者的生活质量有影响。用于测量QoL和认知/行为损害的评估类型存在差异,其中大多数是非特异性疾病。未来研究的建议是使用全面的疾病特异性,多领域措施,以进一步阐明QoL-认知/行为损害关系。