PDF(Pubmed)
Abstract：
BACKGROUND: Quality assurance (QA) and quality control (QC) practices are key tenets that facilitate study and data quality across all applications of untargeted metabolomics. These important practices will strengthen this field and accelerate its success. The Best Practices Working Group (WG) within the Metabolomics Quality Assurance and Quality Control Consortium (mQACC) focuses on community use of QA/QC practices and protocols and aims to identify, catalogue, harmonize, and disseminate current best practices in untargeted metabolomics through community-driven activities.
OBJECTIVE: A present goal of the Best Practices WG is to develop a working strategy, or roadmap, that guides the actions of practitioners and progress in the field. The framework in which mQACC operates promotes the harmonization and dissemination of current best QA/QC practice guidance and encourages widespread adoption of these essential QA/QC activities for liquid chromatography-mass spectrometry.
UNASSIGNED: Community engagement and QA/QC information gathering activities have been occurring through conference workshops, virtual and in-person interactive forum discussions, and community surveys. Seven principal QC stages prioritized by internal discussions of the Best Practices WG have received participant input, feedback and discussion. We outline these stages, each involving a multitude of activities, as the framework for identifying QA/QC best practices. The ultimate planned product of these endeavors is a \"living guidance\" document of current QA/QC best practices for untargeted metabolomics that will grow and change with the evolution of the field.
OBJECTIVE: A present goal of the Best Practices WG is to develop a working strategy, or roadmap, that guides the actions of practitioners and progress in the field. The framework in which mQACC operates promotes the harmonization and dissemination of current best QA/QC practice guidance and encourages widespread adoption of these essential QA/QC activities for liquid chromatography-mass spectrometry.
UNASSIGNED: Community engagement and QA/QC information gathering activities have been occurring through conference workshops, virtual and in-person interactive forum discussions, and community surveys. Seven principal QC stages prioritized by internal discussions of the Best Practices WG have received participant input, feedback and discussion. We outline these stages, each involving a multitude of activities, as the framework for identifying QA/QC best practices. The ultimate planned product of these endeavors is a \"living guidance\" document of current QA/QC best practices for untargeted metabolomics that will grow and change with the evolution of the field.
摘要：
背景：质量保证（QA）和质量控制（QC）实践是促进非靶向代谢组学所有应用的研究和数据质量的关键原则。这些重要做法将加强这一领域并加速其成功。代谢组学质量保证和质量控制联盟（mQACC）内的最佳实践工作组（WG）专注于社区使用QA/QC实践和协议，旨在确定，目录,协调,并通过社区驱动的活动传播当前非目标代谢组学的最佳实践。
目标：最佳实践工作组的当前目标是制定工作策略，或路线图，指导从业者的行动和领域的进步。mQACC运作的框架促进了当前最佳QA/QC实践指南的协调和传播，并鼓励广泛采用这些基本的QA/QC活动进行液相色谱-质谱。
■通过会议研讨会开展社区参与和QA/QC信息收集活动，虚拟和亲自互动论坛讨论，和社区调查。通过最佳实践工作组的内部讨论优先考虑的七个主要质量控制阶段已收到参与者的意见，反馈和讨论。我们概述了这些阶段，每个都涉及许多活动，作为确定QA/QC最佳实践的框架。这些努力的最终计划产品是当前非目标代谢组学QA/QC最佳实践的“生活指导”文件，该文件将随着该领域的发展而发展和变化。
目标：最佳实践工作组的当前目标是制定工作策略，或路线图，指导从业者的行动和领域的进步。mQACC运作的框架促进了当前最佳QA/QC实践指南的协调和传播，并鼓励广泛采用这些基本的QA/QC活动进行液相色谱-质谱。
■通过会议研讨会开展社区参与和QA/QC信息收集活动，虚拟和亲自互动论坛讨论，和社区调查。通过最佳实践工作组的内部讨论优先考虑的七个主要质量控制阶段已收到参与者的意见，反馈和讨论。我们概述了这些阶段，每个都涉及许多活动，作为确定QA/QC最佳实践的框架。这些努力的最终计划产品是当前非目标代谢组学QA/QC最佳实践的“生活指导”文件，该文件将随着该领域的发展而发展和变化。
