PDF(Pubmed)
Abstract：
UNASSIGNED: The aim of the study was to report a case of ocular adverse events following influenza vaccination which involved bilateral myopic shift, ciliochoroidal effusion, and fine retinal folds in a middle-aged woman.
UNASSIGNED: A 42-year-old female presented with sudden-onset painless binocular decreased distance vision. She had received a quadrivalent influenza vaccine (Influvac Tetra) injection 10 days prior, a few days after which she experienced blurred vision. Her initial uncorrected visual acuity and refraction were 20/200 and -3.00/-1.00 × 180 in the right eye, 20/100 and -3.00/-0.50 × 50 in the left eye. Intraocular pressure was within normal limits bilaterally. Anterior segment examination was significant for bilateral shallow anterior chambers (AC) and narrow iridocorneal angles with no cells or flare. Fundus examination was notable for bilateral fine chorioretinal folds radiating from the macula and bilateral low-lying choroidal effusion in the far periphery. Ultrasound biomicroscopy confirmed bilateral ciliochoroidal effusions, shallow AC, and anterior rotation of the ciliary bodies. The patient was started on oral and topical corticosteroids plus atropine and timolol eye drops after which prompt improvement was observed. Restoration of visual acuity and complete resolution of the symptoms without any further complication were observed after 2 weeks.
UNASSIGNED: The temporal association between the onset of the patient\'s symptoms and influenza vaccination, in the absence of any pertinent medical conditions or medications, significantly implicates causality. Future research and case reports can help in corroborating this ocular adverse event attributed to influenza vaccination.
UNASSIGNED: A 42-year-old female presented with sudden-onset painless binocular decreased distance vision. She had received a quadrivalent influenza vaccine (Influvac Tetra) injection 10 days prior, a few days after which she experienced blurred vision. Her initial uncorrected visual acuity and refraction were 20/200 and -3.00/-1.00 × 180 in the right eye, 20/100 and -3.00/-0.50 × 50 in the left eye. Intraocular pressure was within normal limits bilaterally. Anterior segment examination was significant for bilateral shallow anterior chambers (AC) and narrow iridocorneal angles with no cells or flare. Fundus examination was notable for bilateral fine chorioretinal folds radiating from the macula and bilateral low-lying choroidal effusion in the far periphery. Ultrasound biomicroscopy confirmed bilateral ciliochoroidal effusions, shallow AC, and anterior rotation of the ciliary bodies. The patient was started on oral and topical corticosteroids plus atropine and timolol eye drops after which prompt improvement was observed. Restoration of visual acuity and complete resolution of the symptoms without any further complication were observed after 2 weeks.
UNASSIGNED: The temporal association between the onset of the patient\'s symptoms and influenza vaccination, in the absence of any pertinent medical conditions or medications, significantly implicates causality. Future research and case reports can help in corroborating this ocular adverse event attributed to influenza vaccination.
摘要：
■本研究的目的是报告一例流感疫苗接种后眼部不良事件，涉及双侧近视转移，脉络膜积液,和一个中年妇女的精细视网膜褶皱。
■一名42岁女性出现突发性无痛双眼远距视力下降。她在10天前接受了四价流感疫苗（InfluvacTetra）注射，几天后，她经历了视力模糊。她的右眼初始未矫正视力和屈光度为20/200和-3.00/-1.00×180，左眼20/100和-3.00/-0.50×50。双侧眼压在正常范围内。对于双侧浅前房（AC）和狭窄的虹膜角膜角度，无细胞或耀斑，前段检查具有重要意义。眼底检查值得注意的是，从黄斑辐射出的双侧细脉络膜视网膜褶皱和远周边的双侧低洼脉络膜积液。超声生物显微镜检查证实双侧纤毛脉络膜积液，浅交流,和睫状体的前旋转。患者开始口服和局部使用皮质类固醇加阿托品和噻吗洛尔滴眼液，然后观察到迅速改善。2周后观察到视力恢复和症状完全缓解，没有任何进一步的并发症。
■患者症状发作与流感疫苗接种之间的时间关联，在没有任何相关医疗条件或药物的情况下，显着牵涉到因果关系。未来的研究和病例报告可以帮助证实这种归因于流感疫苗接种的眼部不良事件。
■一名42岁女性出现突发性无痛双眼远距视力下降。她在10天前接受了四价流感疫苗（InfluvacTetra）注射，几天后，她经历了视力模糊。她的右眼初始未矫正视力和屈光度为20/200和-3.00/-1.00×180，左眼20/100和-3.00/-0.50×50。双侧眼压在正常范围内。对于双侧浅前房（AC）和狭窄的虹膜角膜角度，无细胞或耀斑，前段检查具有重要意义。眼底检查值得注意的是，从黄斑辐射出的双侧细脉络膜视网膜褶皱和远周边的双侧低洼脉络膜积液。超声生物显微镜检查证实双侧纤毛脉络膜积液，浅交流,和睫状体的前旋转。患者开始口服和局部使用皮质类固醇加阿托品和噻吗洛尔滴眼液，然后观察到迅速改善。2周后观察到视力恢复和症状完全缓解，没有任何进一步的并发症。
■患者症状发作与流感疫苗接种之间的时间关联，在没有任何相关医疗条件或药物的情况下，显着牵涉到因果关系。未来的研究和病例报告可以帮助证实这种归因于流感疫苗接种的眼部不良事件。
