UNASSIGNED: To perform a systematic review of the RCTs in the literature to evaluate the use of TXA on ARCR.
UNASSIGNED: Meta-analysis; Level of evidence, 1.
UNASSIGNED: Two independent reviewers performed the literature search based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, with a third author resolving any discrepancies. RCTs comparing TXA with a control in ARCR were included. Visualization, postoperative pain, operative time, pump pressures, and shoulder swelling were evaluated. A P value < .05 was deemed statistically significant.
UNASSIGNED: Six RCTs with 450 patients were included in this review. Overall, 5 studies evaluated intraoperative visualization, with 3 studies finding a significant difference in favor of TXA. With TXA, patients had a lower mean postoperative visual analog scale (VAS) score of 3.3, and with the control, patients had a mean VAS score of 4.1, which was statistically significant (P = .001). With TXA, the mean weighted operation time was 79.3 minutes, and with the control, the mean operation time was 88.8 minutes, which was statistically significant (P = .001). No study found any difference in intraoperative pump pressures or swelling.
UNASSIGNED: TXA improved visualization, operative time, and subsequent postoperative pain levels in patients undergoing ARCR.
■对文献中的RCT进行系统回顾,以评估TXA在ARCR上的使用。
■荟萃分析;证据水平,1.
■两名独立审稿人根据PRISMA(系统审查和荟萃分析的首选报告项目)指南进行了文献检索,与第三作者解决任何差异。包括将TXA与ARCR中的对照进行比较的RCTs。可视化,术后疼痛,手术时间,泵压力,并对肩关节肿胀进行了评估。P值<0.05被认为具有统计学意义。
■共有450名患者的6个RCT纳入本综述。总的来说,5项研究评估了术中可视化,3项研究发现对TXA有显著差异。有了TXA,患者术后平均视觉模拟量表(VAS)评分较低,为3.3分,与对照组相比,患者的平均VAS评分为4.1分,有统计学意义(P=.001).有了TXA,平均加权手术时间为79.3分钟,有了控制,平均手术时间为88.8分钟,具有统计学意义(P=0.001)。没有研究发现术中泵压或肿胀有任何差异。
■TXA改进了可视化,手术时间,以及接受ARCR的患者术后疼痛水平。