Abstract：
UNASSIGNED: Several randomized controlled trials (RCTs) have been conducted to assess the use of tranexamic acid (TXA) in the setting of arthroscopic rotator cuff repair (ARCR). However, these studies have shown mixed results, with some showing improved intraoperative visualization, subsequent operative times, and pain levels, and others finding no difference.
UNASSIGNED: To perform a systematic review of the RCTs in the literature to evaluate the use of TXA on ARCR.
UNASSIGNED: Meta-analysis; Level of evidence, 1.
UNASSIGNED: Two independent reviewers performed the literature search based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, with a third author resolving any discrepancies. RCTs comparing TXA with a control in ARCR were included. Visualization, postoperative pain, operative time, pump pressures, and shoulder swelling were evaluated. A P value < .05 was deemed statistically significant.
UNASSIGNED: Six RCTs with 450 patients were included in this review. Overall, 5 studies evaluated intraoperative visualization, with 3 studies finding a significant difference in favor of TXA. With TXA, patients had a lower mean postoperative visual analog scale (VAS) score of 3.3, and with the control, patients had a mean VAS score of 4.1, which was statistically significant (P = .001). With TXA, the mean weighted operation time was 79.3 minutes, and with the control, the mean operation time was 88.8 minutes, which was statistically significant (P = .001). No study found any difference in intraoperative pump pressures or swelling.
UNASSIGNED: TXA improved visualization, operative time, and subsequent postoperative pain levels in patients undergoing ARCR.
UNASSIGNED: To perform a systematic review of the RCTs in the literature to evaluate the use of TXA on ARCR.
UNASSIGNED: Meta-analysis; Level of evidence, 1.
UNASSIGNED: Two independent reviewers performed the literature search based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, with a third author resolving any discrepancies. RCTs comparing TXA with a control in ARCR were included. Visualization, postoperative pain, operative time, pump pressures, and shoulder swelling were evaluated. A P value < .05 was deemed statistically significant.
UNASSIGNED: Six RCTs with 450 patients were included in this review. Overall, 5 studies evaluated intraoperative visualization, with 3 studies finding a significant difference in favor of TXA. With TXA, patients had a lower mean postoperative visual analog scale (VAS) score of 3.3, and with the control, patients had a mean VAS score of 4.1, which was statistically significant (P = .001). With TXA, the mean weighted operation time was 79.3 minutes, and with the control, the mean operation time was 88.8 minutes, which was statistically significant (P = .001). No study found any difference in intraoperative pump pressures or swelling.
UNASSIGNED: TXA improved visualization, operative time, and subsequent postoperative pain levels in patients undergoing ARCR.
摘要：
■已经进行了几项随机对照试验（RCT），以评估氨甲环酸（TXA）在关节镜肩袖修复（ARCR）中的使用。然而,这些研究显示了不同的结果，一些显示出改进的术中可视化，随后的手术时间，和疼痛程度，和其他人发现没有区别。
■对文献中的RCT进行系统回顾，以评估TXA在ARCR上的使用。
■荟萃分析；证据水平，1.
■两名独立审稿人根据PRISMA（系统审查和荟萃分析的首选报告项目）指南进行了文献检索，与第三作者解决任何差异。包括将TXA与ARCR中的对照进行比较的RCTs。可视化,术后疼痛,手术时间,泵压力,并对肩关节肿胀进行了评估。P值<0.05被认为具有统计学意义。
■共有450名患者的6个RCT纳入本综述。总的来说,5项研究评估了术中可视化，3项研究发现对TXA有显著差异。有了TXA,患者术后平均视觉模拟量表(VAS)评分较低，为3.3分，与对照组相比，患者的平均VAS评分为4.1分,有统计学意义(P=.001).有了TXA,平均加权手术时间为79.3分钟，有了控制，平均手术时间为88.8分钟，具有统计学意义（P=0.001）。没有研究发现术中泵压或肿胀有任何差异。
■TXA改进了可视化，手术时间,以及接受ARCR的患者术后疼痛水平。
■对文献中的RCT进行系统回顾，以评估TXA在ARCR上的使用。
■荟萃分析；证据水平，1.
■两名独立审稿人根据PRISMA（系统审查和荟萃分析的首选报告项目）指南进行了文献检索，与第三作者解决任何差异。包括将TXA与ARCR中的对照进行比较的RCTs。可视化,术后疼痛,手术时间,泵压力,并对肩关节肿胀进行了评估。P值<0.05被认为具有统计学意义。
■共有450名患者的6个RCT纳入本综述。总的来说,5项研究评估了术中可视化，3项研究发现对TXA有显著差异。有了TXA,患者术后平均视觉模拟量表(VAS)评分较低，为3.3分，与对照组相比，患者的平均VAS评分为4.1分,有统计学意义(P=.001).有了TXA,平均加权手术时间为79.3分钟，有了控制，平均手术时间为88.8分钟，具有统计学意义（P=0.001）。没有研究发现术中泵压或肿胀有任何差异。
■TXA改进了可视化，手术时间,以及接受ARCR的患者术后疼痛水平。
