Abstract：
IBS is a prevalent clinical condition affecting bowel function. There is a restricted comprehension of its pathogenesis, an absence of particular diagnostic tools, and an insufficiency of efficient pharmacological remedies. MiRNAs are a highly conserved class of non-coding small molecule RNAs, with a length of 20-24 nucleotides. Research has shown the presence of a number of differentially expressed miRNAs in the colonic tissue and peripheral blood of IBS patients. Meanwhile, miRNAs have a critical role in gene expression and the pathology of IBS as they act as significant mediators of post-transcriptional gene silencing. The investigation of miRNA molecular regulatory networks proves useful in examining the convoluted pathogenesis of IBS. This paper presents a review of recent literature on miRNAs associated with IBS, explains how miRNAs contribute to the development of IBS, and assesses the potential usefulness of miRNA analysis for diagnosing and treating IBS.
摘要：
IBS是影响肠功能的普遍临床病症。对其发病机理的理解有限，缺乏特定的诊断工具，和有效的药理学补救措施的不足。miRNA是一类高度保守的非编码小分子RNA,长度为20-24个核苷酸。研究表明，IBS患者的结肠组织和外周血中存在许多差异表达的miRNA。同时,miRNA在IBS的基因表达和病理学中起关键作用,因为它们充当转录后基因沉默的重要介质。miRNA分子调控网络的研究证明可用于检查IBS的复杂发病机理。本文综述了与IBS相关的miRNA的最新文献。解释了miRNAs如何促进IBS的发展，并评估miRNA分析对诊断和治疗IBS的潜在有用性。
