{Reference Type}: Journal Article
{Title}: The role of miRNA in IBS pathogenesis, diagnosis and therapy: The latest thought.
{Author}: Zhang X;Shi L;Chen C;Ma Y;Ma Y;
{Journal}: Dig Liver Dis
{Volume}: 56
{Issue}: 9
{Year}: 2024 Sep 10
{Factor}: 5.165
{DOI}: 10.1016/j.dld.2024.01.209
{Abstract}: IBS is a prevalent clinical condition affecting bowel function. There is a restricted comprehension of its pathogenesis, an absence of particular diagnostic tools, and an insufficiency of efficient pharmacological remedies. MiRNAs are a highly conserved class of non-coding small molecule RNAs, with a length of 20-24 nucleotides. Research has shown the presence of a number of differentially expressed miRNAs in the colonic tissue and peripheral blood of IBS patients. Meanwhile, miRNAs have a critical role in gene expression and the pathology of IBS as they act as significant mediators of post-transcriptional gene silencing. The investigation of miRNA molecular regulatory networks proves useful in examining the convoluted pathogenesis of IBS. This paper presents a review of recent literature on miRNAs associated with IBS, explains how miRNAs contribute to the development of IBS, and assesses the potential usefulness of miRNA analysis for diagnosing and treating IBS.