PDF(Pubmed)
Abstract：
BACKGROUND: This study aimed to compare the balance ability and functional brain oxygenation in the prefrontal cortex (PFC) among older adults with mild cognitive impairment (MCI) under single and dual tasks, and also investigate their relationship. Neural regulatory mechanisms of the brain in the MCI were shed light on in balance control conditions.
METHODS: 21 older adults with MCI (female = 12, age: 71.19 ± 3.36 years) were recruited as the experimental group and 19 healthy older adults (female = 9, age: 70.16 ± 4.54 years) as the control group. Participants completed balance control of single task and dual task respectively. Functional near-infrared spectroscopy (fNIRS) and force measuring platform are used to collect hemodynamic signals of the PFC and center of pressure (COP) data during the balance task, respectively.
RESULTS: The significant Group*Task interaction effect was found in maximal displacement of the COP in the medial-lateral (ML) direction (D-ml), 95% confidence ellipse area (95%AREA), root mean square (RMS), the RMS in the ML direction (RMS-ml), the RMS in the anterior-posterior (AP) direction (RMS-ap), sway path (SP), the sway path in the ML direction (SP-ml), and the sway path in the AP direction (SP-ap). The significant group effect was detected for five regions of interest (ROI), namely the left Brodmann area (BA) 45 (L45), the right BA45 (R45), the right BA10 (R10), the left BA46 (L46), and the right BA11 (R11). Under single task, maximal displacement of the COP in the AP direction (D-ap), RMS, and RMS-ap were significantly negatively correlated with R45, L45, and R11 respectively. Under dual task, both RMS and 95%AREA were correlated positively with L45, and both L10 and R10 were positively correlated with RMS-ap.
CONCLUSIONS: The MCI demonstrated worse balance control ability as compared to healthy older adults. The greater activation of PFC under dual tasks in MCI may be considered a compensatory strategy for maintaining the standing balance. The brain activation was negatively correlated with balance ability under single task, and positively under dual task.
BACKGROUND: ChiCTR2100044221 , 12/03/2021.
METHODS: 21 older adults with MCI (female = 12, age: 71.19 ± 3.36 years) were recruited as the experimental group and 19 healthy older adults (female = 9, age: 70.16 ± 4.54 years) as the control group. Participants completed balance control of single task and dual task respectively. Functional near-infrared spectroscopy (fNIRS) and force measuring platform are used to collect hemodynamic signals of the PFC and center of pressure (COP) data during the balance task, respectively.
RESULTS: The significant Group*Task interaction effect was found in maximal displacement of the COP in the medial-lateral (ML) direction (D-ml), 95% confidence ellipse area (95%AREA), root mean square (RMS), the RMS in the ML direction (RMS-ml), the RMS in the anterior-posterior (AP) direction (RMS-ap), sway path (SP), the sway path in the ML direction (SP-ml), and the sway path in the AP direction (SP-ap). The significant group effect was detected for five regions of interest (ROI), namely the left Brodmann area (BA) 45 (L45), the right BA45 (R45), the right BA10 (R10), the left BA46 (L46), and the right BA11 (R11). Under single task, maximal displacement of the COP in the AP direction (D-ap), RMS, and RMS-ap were significantly negatively correlated with R45, L45, and R11 respectively. Under dual task, both RMS and 95%AREA were correlated positively with L45, and both L10 and R10 were positively correlated with RMS-ap.
CONCLUSIONS: The MCI demonstrated worse balance control ability as compared to healthy older adults. The greater activation of PFC under dual tasks in MCI may be considered a compensatory strategy for maintaining the standing balance. The brain activation was negatively correlated with balance ability under single task, and positively under dual task.
BACKGROUND: ChiCTR2100044221 , 12/03/2021.
摘要：
背景：本研究旨在比较轻度认知障碍（MCI）老年人在单任务和双任务下的前额叶皮质（PFC）的平衡能力和功能性脑氧合，并调查他们的关系。在平衡控制条件下，MCI中大脑的神经调节机制得到了阐明。
方法：以21名MCI老年人（女性=12，年龄：71.19±3.36岁）为实验组，19名健康老年人（女性=9，年龄：70.16±4.54岁）为对照组。参与者分别完成单任务和双任务的平衡控制。在平衡任务期间，使用功能近红外光谱（fNIRS）和测力平台收集PFC的血液动力学信号和压力中心（COP）数据。分别。
结果：在COP在内侧-外侧（ML）方向（D-ml）的最大位移中发现了显着的组*任务相互作用效应，95%置信椭圆面积(95%面积),均方根(RMS)，ML方向的RMS(RMS-ml)，前-后(AP)方向的RMS(RMS-AP)，摇摆路径(SP)，ML方向的摇摆路径(SP-ml)，以及AP方向的摇摆路径(SP-ap)。对五个感兴趣区域(ROI)检测到显著的群体效应，即左布罗德曼区(BA)45(L45)，右BA45（R45），右BA10（R10），左侧BA46(L46),和右BA11（R11）。在单一任务下,COP在AP方向(D-AP)上的最大位移，RMS,和RMS-ap分别与R45、L45和R11呈显著负相关。在双重任务下，RMS和95%AREA与L45呈正相关，L10和R10与RMS-ap呈正相关。
结论：与健康老年人相比，MCI表现出更差的平衡控制能力。在MCI的双重任务下，PFC的更大激活可能被认为是维持站立平衡的补偿策略。在单一任务下，大脑激活与平衡能力呈负相关，在双重任务下积极。
背景：ChiCTR2100044221,12/03/2021。
方法：以21名MCI老年人（女性=12，年龄：71.19±3.36岁）为实验组，19名健康老年人（女性=9，年龄：70.16±4.54岁）为对照组。参与者分别完成单任务和双任务的平衡控制。在平衡任务期间，使用功能近红外光谱（fNIRS）和测力平台收集PFC的血液动力学信号和压力中心（COP）数据。分别。
结果：在COP在内侧-外侧（ML）方向（D-ml）的最大位移中发现了显着的组*任务相互作用效应，95%置信椭圆面积(95%面积),均方根(RMS)，ML方向的RMS(RMS-ml)，前-后(AP)方向的RMS(RMS-AP)，摇摆路径(SP)，ML方向的摇摆路径(SP-ml)，以及AP方向的摇摆路径(SP-ap)。对五个感兴趣区域(ROI)检测到显著的群体效应，即左布罗德曼区(BA)45(L45)，右BA45（R45），右BA10（R10），左侧BA46(L46),和右BA11（R11）。在单一任务下,COP在AP方向(D-AP)上的最大位移，RMS,和RMS-ap分别与R45、L45和R11呈显著负相关。在双重任务下，RMS和95%AREA与L45呈正相关，L10和R10与RMS-ap呈正相关。
结论：与健康老年人相比，MCI表现出更差的平衡控制能力。在MCI的双重任务下，PFC的更大激活可能被认为是维持站立平衡的补偿策略。在单一任务下，大脑激活与平衡能力呈负相关，在双重任务下积极。
背景：ChiCTR2100044221,12/03/2021。
