PDF(Pubmed)
Abstract：
Obesity or excessive weight gain is identified as the most important and significant risk factor in the development and progression of type 2 diabetes mellitus (DM) in all age groups. It has reached pandemic dimensions, making the treatment of obesity crucial in the prevention and management of type 2 DM worldwide. Multiple clinical studies have demonstrated that moderate and sustained weight loss can improve blood glucose levels, insulin action and reduce the need for diabetic medications. A combined approach of diet, exercise and lifestyle modifications can successfully reduce obesity and subsequently ameliorate the ill effects and deadly complications of DM. This approach also helps largely in the prevention, control and remission of DM. Obesity and DM are chronic diseases that are increasing globally, requiring new approaches to manage and prevent diabetes in obese individuals. Therefore, it is essential to understand the mechanistic link between the two and design a comprehensive approach to increase life expectancy and improve the quality of life in patients with type 2 DM and obesity. This literature review provides explicit information on the clinical definitions of obesity and type 2 DM, the incidence and prevalence of type 2 DM in obese individuals, the indispensable role of obesity in the pathophysiology of type 2 DM and their mechanistic link. It also discusses clinical studies and outlines the recent management approaches for the treatment of these associated conditions. Additionally, in vivo studies on obesity and type 2 DM are discussed here as they pave the way for more rigorous development of therapeutic approaches.
摘要：
在所有年龄组中，肥胖或过度体重增加被认为是2型糖尿病（DM）发展和进展中最重要和最重要的危险因素。它已经达到了大流行的程度，肥胖的治疗在全球2型糖尿病的预防和管理中至关重要。多项临床研究表明，适度和持续的体重减轻可以改善血糖水平，胰岛素的作用和减少对糖尿病药物的需要。联合饮食的方法，运动和生活方式的改变可以成功地减少肥胖，并随后改善DM的不良影响和致命并发症。这种方法在很大程度上也有助于预防，DM的控制和缓解。肥胖和糖尿病是全球范围内正在增加的慢性疾病，需要新的方法来管理和预防肥胖个体的糖尿病。因此,了解二者之间的机制联系并设计一种综合方法来提高2型糖尿病和肥胖患者的预期寿命和生活质量至关重要.这篇文献综述提供了关于肥胖和2型糖尿病临床定义的明确信息。肥胖个体中2型糖尿病的发病率和患病率，肥胖在2型糖尿病的病理生理学中不可或缺的作用及其机制联系。它还讨论了临床研究，并概述了治疗这些相关疾病的最新管理方法。此外,这里讨论了肥胖和2型糖尿病的体内研究,因为它们为更严格的治疗方法的发展铺平了道路.
