PDF(Pubmed)
Abstract：
In recent years, research has shown that oxidative stress plays a significant role in chronic inflammatory conditions. The alteration of the oxidant/antioxidant balance leads to the appearance of free radicals, important molecules involved in both diabetes mellitus and periodontal disease. Diabetes is considered to be one of the major risk factors of periodontal disease and the inflammation characterizing this condition is associated with oxidative stress, implicitly resulting in oxidative damage to DNA. 8-Hydroxydeoxyguanosine (8-OHdG) is the most common stable product of oxidative DNA damage caused by reactive oxygen species, and its levels have been reported to increase in body fluids and tissues during inflammatory conditions. 8-OHdG emerges as a pivotal biomarker for assessing oxidative DNA damage, demonstrating its relevance across diverse health conditions, including neurodegenerative disorders, cancers, inflammatory conditions, and periodontal disease. Continued research in this field is crucial for developing more precise treatments and understanding the detailed link between oxidative stress and the progression of periodontitis. The use of the 8-OHdG biomarker in assessing and managing chronic periodontitis is an area of increased interest in dental research, with the potential to provide crucial information for diagnosis and treatment.
摘要：
近年来,研究表明，氧化应激在慢性炎症中起着重要作用。氧化剂/抗氧化剂平衡的改变导致自由基的出现，参与糖尿病和牙周病的重要分子。糖尿病被认为是牙周病的主要危险因素之一，其炎症特征与氧化应激有关。隐含地导致DNA的氧化损伤。8-羟基脱氧鸟苷（8-OHdG）是由活性氧引起的氧化性DNA损伤的最常见的稳定产物，据报道，在炎症期间，其水平在体液和组织中增加。8-OHdG成为评估氧化DNA损伤的关键生物标志物，证明其在不同健康状况中的相关性，包括神经退行性疾病，癌症,炎症条件，和牙周病.该领域的持续研究对于开发更精确的治疗方法和了解氧化应激与牙周炎进展之间的详细联系至关重要。在评估和管理慢性牙周炎中使用8-OHdG生物标志物是牙科研究中越来越感兴趣的领域。有可能为诊断和治疗提供关键信息。
