PDF(Pubmed)
Abstract：
Studies have attempted to demonstrate the benefits of silicon on bone health using a wide range of Si amounts-provided in the diet or through supplementation-and several different animal species. Previous studies in humans have also demonstrated a positive correlation between Si intake and bone health measures. The aim of the current review is to determine the effective levels of Si intake or supplementation that influence bone health to better inform future study designs and guidelines. Articles were identified using one of two search terms: \"silicon AND bone\" or \"sodium zeolite A AND bone\". Articles were included if the article was a controlled research study on the effect of Si on bone health and/or mineral metabolism and was in English. Articles were excluded if the article included human subjects, was in vitro, or studied silica grafts for bone injuries. Silicon type, group name, Si intake from diet, Si supplementation amount, animal, and age at the start were extracted when available. Dietary Si intake, Si supplementation amount, and the amount of Si standardized on a kg BW basis were calculated and presented as overall mean ± standard deviations, medians, minimums, and maximums. Studies that left out animal weights, amount of food or water consumed, or nutrient profiles of the basal diet were excluded from these calculations. Standardized Si intakes ranged from 0.003 to 863 mg/kg BW, at times vastly exceeding current human Si intake recommendations (25 mg/d). The lack of data provided by the literature made definitively determining an effective threshold of supplementation for skeletal health difficult. However, it appears that Si consistently positively influences bone and mineral metabolism by around 139 mg Si/kg BW/d, which is likely unfeasible to attain in humans and large animal species. Future studies should examine this proposed threshold more directly and standardize supplemental or dietary Si intakes to kg BW for better study replication and translation.
摘要：
研究已经尝试使用在饮食中或通过补充提供的宽范围的Si量和几种不同的动物物种来证明硅对骨骼健康的益处。先前在人类中的研究也证明了Si摄入量与骨骼健康指标之间的正相关。本综述的目的是确定影响骨骼健康的Si摄入或补充的有效水平，以更好地为未来的研究设计和指南提供信息。使用两个搜索词之一识别文章：“硅和骨骼”或“钠沸石A和骨骼”。如果文章是关于Si对骨健康和/或矿物质代谢的影响的对照研究并且是英文的，则包括文章。如果文章包括人类受试者，则文章被排除在外，在体外，或者研究了骨损伤的二氧化硅移植物。硅类型，组名,从饮食中摄入Si，Si补充量，动物,和年龄在开始时被提取时可用。膳食Si摄入量，Si补充量，并计算以kgBW为基础标准化的Si量，并表示为总体平均值±标准偏差，中位数，最小值,和最大值。研究遗漏了动物体重，消耗的食物或水，或基础饮食的营养概况被排除在这些计算之外。标准化的硅摄入量范围为0.003至863毫克/千克体重，有时大大超过目前的人类硅摄入量建议（25毫克/天）。文献提供的数据的缺乏使得难以确定骨骼健康的有效补充阈值。然而,似乎Si始终对骨骼和矿物质代谢产生约139mgSi/kgBW/d的积极影响，这在人类和大型动物物种中可能是不可行的。未来的研究应更直接地检查此建议的阈值，并将补充或饮食中的Si摄入量标准化为kgBW，以更好地复制和翻译研究。
