PDF(Pubmed)
Abstract：
The application of biopolymers in the reconstruction of the posterior lamella of the eyelid and the lacrimal system marks a significant fusion of biomaterial science with clinical advancements. This review assimilates research spanning 2015 to 2023 to provide a detailed examination of the role of biopolymers in reconstructing the posterior lamella of the eyelid and the lacrimal system. It covers the anatomy and pathophysiology of eyelid structures, the challenges of reconstruction, and the nuances of surgical intervention. This article progresses to evaluate the current gold standards, alternative options, and the desirable properties of biopolymers used in these intricate procedures. It underscores the advancements in the field, from decellularized grafts and acellular matrices to innovative natural and synthetic polymers, and explores their applications in lacrimal gland tissue engineering, including the promise of 3D bioprinting technologies. This review highlights the importance of multidisciplinary collaboration between material scientists and clinicians in enhancing surgical outcomes and patient quality of life, emphasizing that such cooperation is pivotal for translating benchtop research into bedside applications. This collaborative effort is vital for restoring aesthetics and functionality for patients afflicted with disfiguring eyelid diseases, ultimately aiming to bridge the gap between innovative materials and their clinical translation.
摘要：
生物聚合物在眼睑和泪道系统后层重建中的应用标志着生物材料科学与临床进步的重要融合。这篇综述吸收了2015年至2023年的研究，以详细研究生物聚合物在重建眼睑后层和泪道系统中的作用。它涵盖了眼睑结构的解剖学和病理生理学，重建的挑战，以及手术干预的细微差别。本文进展到评估当前的黄金标准，替代选项，以及这些复杂程序中使用的生物聚合物的理想特性。它强调了该领域的进步，从脱细胞移植物和无细胞基质到创新的天然和合成聚合物，并探讨了它们在泪腺组织工程中的应用，包括3D生物打印技术的承诺。这篇综述强调了材料科学家和临床医生之间的多学科合作在提高手术结果和患者生活质量方面的重要性。强调这种合作对于将台式研究转化为床边应用至关重要。这种协作努力对于恢复患有眼睑疾病的患者的美学和功能至关重要，最终旨在弥合创新材料与其临床翻译之间的差距。
