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Abstract：
Several studies have highlighted the functional indispensability of methyltransferase-like 3 (METTL3) in the reproductive system. However, a review that comprehensively interprets these studies and elucidates their relationships is lacking. Therefore, the present work aimed to review studies that have investigated the functions of METTL3 in the reproductive system (including spermatogenesis, follicle development, gametogenesis, reproductive cancer, asthenozoospermia and assisted reproduction failure). This review suggests that METTL3 functions not only essential for normal development, but also detrimental in the occurrence of disorders. In addition, promising applications of METTL3 as a diagnostic or prognostic biomarker and therapeutic target for reproductive disorders have been proposed. Collectively, this review provides comprehensive interpretations, novel insights, potential applications and future perspectives on the role of METTL3 in regulating the reproductive system, which may be a valuable reference for researchers and clinicians.
摘要：
一些研究强调了类甲基转移酶3（METTL3）在生殖系统中的功能不可或缺性。然而,缺乏全面解释这些研究并阐明它们之间关系的评论。因此,本工作旨在回顾研究METTL3在生殖系统中的功能（包括精子发生，卵泡发育,配子发生,生殖癌症,弱精子症和辅助生殖衰竭）。这篇综述表明，METTL3的功能不仅对正常发育至关重要，但也不利于疾病的发生。此外,已经提出了METTL3作为生殖疾病的诊断或预后生物标志物和治疗靶标的有希望的应用。总的来说，这篇综述提供了全面的解释，新颖的见解，关于METTL3在调节生殖系统中的作用的潜在应用和未来观点，这对于研究者和临床医生来说可能是一个有价值的参考。
