Abstract：
OBJECTIVE: Tumor of follicular infundibulum (TFI) has been described as a neoplasm - isolated and multiple - and in association with other lesions. Its histopathologic definition is controversial.
METHODS: We present a histopathologically analyzed series of 28 patients with TFI features. This has been supplemented by a search in MEDLINE on the literature on this subject. The corresponding figures given in these articles have been discussed and analyzed.
RESULTS: Patients comprised 16 women and twelve men. TFI features were seen in five patients with nevus sebaceous, two trichofolliculomas, one dilated pore Winer, eight viral warts, one dermatofibroma, six seborrheic keratoses, three actinic keratoses, one invasive squamous cell carcinoma, and one basal cell carcinoma in association with a squamous cell carcinoma/actinic keratosis. After study of the literature especially of solitary cases of TFI, we interpret such cases mostly as variants of seborrheic keratoses with variable degree of infundibular, isthmic and/or sebaceous differentiation with or without regression.
CONCLUSIONS: We regard TFI as an epithelial growth pattern which may occur in hamartomatous, inflammatory, infectious, reactive, or neoplastic conditions, in most solitary forms likely best classified within the histopathological spectrum of seborrheic keratoses.
METHODS: We present a histopathologically analyzed series of 28 patients with TFI features. This has been supplemented by a search in MEDLINE on the literature on this subject. The corresponding figures given in these articles have been discussed and analyzed.
RESULTS: Patients comprised 16 women and twelve men. TFI features were seen in five patients with nevus sebaceous, two trichofolliculomas, one dilated pore Winer, eight viral warts, one dermatofibroma, six seborrheic keratoses, three actinic keratoses, one invasive squamous cell carcinoma, and one basal cell carcinoma in association with a squamous cell carcinoma/actinic keratosis. After study of the literature especially of solitary cases of TFI, we interpret such cases mostly as variants of seborrheic keratoses with variable degree of infundibular, isthmic and/or sebaceous differentiation with or without regression.
CONCLUSIONS: We regard TFI as an epithelial growth pattern which may occur in hamartomatous, inflammatory, infectious, reactive, or neoplastic conditions, in most solitary forms likely best classified within the histopathological spectrum of seborrheic keratoses.
摘要：
目的：滤泡漏斗状肿瘤（TFI）被描述为一种孤立的和多发性的肿瘤，并与其他病变相关。其组织病理学定义存在争议。
方法：我们对28例具有TFI特征的患者进行了一系列组织病理学分析。在MEDLINE中搜索了有关该主题的文献，对此进行了补充。这些文章中给出的相应数字已经进行了讨论和分析。
结果：患者包括16名女性和12名男性。TFI特征见于5例皮脂腺痣患者，两个毛滴虫瘤,一个扩张毛孔的Winer,八个病毒性疣,一个皮肤纤维瘤,六种脂溢性角化病，三个光化性角化病，一个浸润性鳞状细胞癌,和一个与鳞状细胞癌/光化性角化相关的基底细胞癌。在研究了文献，特别是单独的TFI病例之后，我们将此类病例解释为脂溢性角化病的变体，具有不同程度的漏斗，峡部和/或皮脂腺分化有或没有消退。
结论：我们认为TFI是一种上皮生长模式，可能发生在错构瘤中，炎症，传染性,reactive,或者肿瘤状况，在大多数孤立形式中，最可能属于脂溢性角化病的组织病理学范围。
方法：我们对28例具有TFI特征的患者进行了一系列组织病理学分析。在MEDLINE中搜索了有关该主题的文献，对此进行了补充。这些文章中给出的相应数字已经进行了讨论和分析。
结果：患者包括16名女性和12名男性。TFI特征见于5例皮脂腺痣患者，两个毛滴虫瘤,一个扩张毛孔的Winer,八个病毒性疣,一个皮肤纤维瘤,六种脂溢性角化病，三个光化性角化病，一个浸润性鳞状细胞癌,和一个与鳞状细胞癌/光化性角化相关的基底细胞癌。在研究了文献，特别是单独的TFI病例之后，我们将此类病例解释为脂溢性角化病的变体，具有不同程度的漏斗，峡部和/或皮脂腺分化有或没有消退。
结论：我们认为TFI是一种上皮生长模式，可能发生在错构瘤中，炎症，传染性,reactive,或者肿瘤状况，在大多数孤立形式中，最可能属于脂溢性角化病的组织病理学范围。
