%0 Review
%T Tumor of follicular infundibulum - reappraisal in a series of 28 patients with critical review of the literature.
%A Wilk M
%A Zelger BG
%A Zelger B
%J J Dtsch Dermatol Ges
%V 22
%N 2
%D 2024 Feb 8
%M 38332423
%F 5.231
%R 10.1111/ddg.15296
%X <B>OBJECTIVE: </B>Tumor of follicular infundibulum (TFI) has been described as a neoplasm - isolated and multiple - and in association with other lesions. Its histopathologic definition is controversial.<BR><B>METHODS: </B>We present a histopathologically analyzed series of 28 patients with TFI features. This has been supplemented by a search in MEDLINE on the literature on this subject. The corresponding figures given in these articles have been discussed and analyzed.<BR><B>RESULTS: </B>Patients comprised 16 women and twelve men. TFI features were seen in five patients with nevus sebaceous, two trichofolliculomas, one dilated pore Winer, eight viral warts, one dermatofibroma, six seborrheic keratoses, three actinic keratoses, one invasive squamous cell carcinoma, and one basal cell carcinoma in association with a squamous cell carcinoma/actinic keratosis. After study of the literature especially of solitary cases of TFI, we interpret such cases mostly as variants of seborrheic keratoses with variable degree of infundibular, isthmic and/or sebaceous differentiation with or without regression.<BR><B>CONCLUSIONS: </B>We regard TFI as an epithelial growth pattern which may occur in hamartomatous, inflammatory, infectious, reactive, or neoplastic conditions, in most solitary forms likely best classified within the histopathological spectrum of seborrheic keratoses.