PDF(Pubmed)
Abstract：
BACKGROUND: Lewy body dementia (LBD) ranks second among prevalent neurodegenerative dementias. Previous studies have revealed associations of serum lipid measures with several neurodegenerative diseases. Nevertheless, the potential connection between serum lipids and LBD remains undetermined. In this study, Mendelian randomization (MR) analyses were carried out to assess the causal relationships of several serum lipid measures with the risk of developing LBD.
METHODS: Genome-wide association study (GWAS) data for serum lipids and LBD in European descent individuals were acquired from publicly available genetic summary data. A series of filtering procedures were conducted to identify the genetic variant candidates that are related to serum lipids, including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). The causal effects were primarily determined through inverse-variance weighting (IVW)-based analyses.
RESULTS: Neither TG (odds ratio [OR] = 1.149; 95% confidence interval [CI], 0.887-1.489; P = 0.293) nor HDL-C (OR = 0.864; 95% CI, 0.718-1.041; P = 0.124) had causal effects on LBD. However, a causal relationship was identified between LDL-C and LBD (OR = 1.343; 95% CI, 1.094-1.649; P = 0.005), which remained significant (OR = 1.237; 95% CI, 1.015-1.508; P = 0.035) following adjustment for HDL-C and TG in multivariable MR.
CONCLUSIONS: Elevated serum LDL-C increases the risk of LBD, while HDL-C and TG have no significant causal effects on LBD.
METHODS: Genome-wide association study (GWAS) data for serum lipids and LBD in European descent individuals were acquired from publicly available genetic summary data. A series of filtering procedures were conducted to identify the genetic variant candidates that are related to serum lipids, including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). The causal effects were primarily determined through inverse-variance weighting (IVW)-based analyses.
RESULTS: Neither TG (odds ratio [OR] = 1.149; 95% confidence interval [CI], 0.887-1.489; P = 0.293) nor HDL-C (OR = 0.864; 95% CI, 0.718-1.041; P = 0.124) had causal effects on LBD. However, a causal relationship was identified between LDL-C and LBD (OR = 1.343; 95% CI, 1.094-1.649; P = 0.005), which remained significant (OR = 1.237; 95% CI, 1.015-1.508; P = 0.035) following adjustment for HDL-C and TG in multivariable MR.
CONCLUSIONS: Elevated serum LDL-C increases the risk of LBD, while HDL-C and TG have no significant causal effects on LBD.
摘要：
背景：路易体痴呆（LBD）在普遍的神经退行性痴呆中排名第二。先前的研究已经揭示了血清脂质测量与几种神经退行性疾病的关联。然而，血脂与LBD之间的潜在联系仍未确定.在这项研究中,进行了孟德尔随机化（MR）分析，以评估几种血脂指标与发展LBD风险的因果关系。
方法：欧洲血统个体的血脂和LBD的全基因组关联研究（GWAS）数据来自公开的遗传汇总数据。进行了一系列过滤程序以鉴定与血清脂质相关的遗传变异候选物。包括高密度脂蛋白胆固醇（HDL-C），低密度脂蛋白胆固醇（LDL-C），和甘油三酯(TG)。因果效应主要通过基于方差逆加权(IVW)的分析来确定。
结果：均无TG(比值比[OR]=1.149；95%置信区间[CI]，0.887-1.489；P=0.293）和HDL-C（OR=0.864；95％CI，0.718-1.041；P=0.124）对LBD有因果关系。然而,LDL-C与LBD之间存在因果关系（OR=1.343；95％CI，1.094-1.649；P=0.005），在多变量MR中调整HDL-C和TG后，其仍然显着（OR=1.237；95％CI，1.015-1.508；P=0.035）。
结论：血清LDL-C升高会增加LBD的风险，HDL-C和TG对LBD无显著因果效应。
方法：欧洲血统个体的血脂和LBD的全基因组关联研究（GWAS）数据来自公开的遗传汇总数据。进行了一系列过滤程序以鉴定与血清脂质相关的遗传变异候选物。包括高密度脂蛋白胆固醇（HDL-C），低密度脂蛋白胆固醇（LDL-C），和甘油三酯(TG)。因果效应主要通过基于方差逆加权(IVW)的分析来确定。
结果：均无TG(比值比[OR]=1.149；95%置信区间[CI]，0.887-1.489；P=0.293）和HDL-C（OR=0.864；95％CI，0.718-1.041；P=0.124）对LBD有因果关系。然而,LDL-C与LBD之间存在因果关系（OR=1.343；95％CI，1.094-1.649；P=0.005），在多变量MR中调整HDL-C和TG后，其仍然显着（OR=1.237；95％CI，1.015-1.508；P=0.035）。
结论：血清LDL-C升高会增加LBD的风险，HDL-C和TG对LBD无显著因果效应。
