Abstract:
Synthetic polymers, particularly polyurethanes (PUs), have revolutionized bioengineering and biomedical devices due to their customizable mechanical properties and long-term stability. However, the inherent hydrophobic nature of PU surfaces arises common issues such as high friction, strong protein adsorption, and thrombosis, especially in the physiological environment of blood contact. To overcome these issues, researchers have explored various modification techniques to improve the surface biofunctionality of PUs. In this review, we have systematically summarized several typical surface modification methods including surface plasma modification, surface oxidation-induced grafting polymerization, isocyanate-based chemistry coupling, UV-induced surface grafting polymerization, adhesives-assisted attachment strategy, small molecules-bridge grafting, solvent evaporation technique, and hydrogen bonding interaction. Correspondingly, the advantages, limitations, and future prospects of these surface modification methods were discussed. This review provides an important guidance or tool for developing surface functionalized PUs in the fields of bioengineering and medical devices.
摘要:
合成聚合物,特别是聚氨酯(PU),具有革命性的生物工程和生物医学设备,由于其可定制的机械性能和长期稳定性。然而,PU表面固有的疏水性质出现常见的问题,如高摩擦,强蛋白质吸附,和血栓形成,尤其是在血液接触的生理环境中。为了克服这些问题,研究人员已经探索了各种改性技术来提高PU的表面生物功能。在这次审查中,我们系统地总结了几种典型的表面改性方法,包括表面等离子体改性,表面氧化诱导接枝聚合,异氰酸酯基化学偶联,紫外诱导表面接枝聚合,粘合剂辅助附着策略,小分子桥接枝,溶剂蒸发技术,和氢键相互作用。相应地,的优势,局限性,并对这些表面改性方法的前景进行了展望。这篇综述为在生物工程和医疗设备领域开发表面功能化PU提供了重要的指导或工具。