{Reference Type}: Journal Article
{Title}: Surface functionalization of polyurethanes: A critical review.
{Author}: Zhang J;Lv S;Zhao X;Ma S;Zhou F;
{Journal}: Adv Colloid Interface Sci
{Volume}: 325
{Issue}: 0
{Year}: 2024 Mar 4
{Factor}: 15.19
{DOI}: 10.1016/j.cis.2024.103100
{Abstract}: Synthetic polymers, particularly polyurethanes (PUs), have revolutionized bioengineering and biomedical devices due to their customizable mechanical properties and long-term stability. However, the inherent hydrophobic nature of PU surfaces arises common issues such as high friction, strong protein adsorption, and thrombosis, especially in the physiological environment of blood contact. To overcome these issues, researchers have explored various modification techniques to improve the surface biofunctionality of PUs. In this review, we have systematically summarized several typical surface modification methods including surface plasma modification, surface oxidation-induced grafting polymerization, isocyanate-based chemistry coupling, UV-induced surface grafting polymerization, adhesives-assisted attachment strategy, small molecules-bridge grafting, solvent evaporation technique, and hydrogen bonding interaction. Correspondingly, the advantages, limitations, and future prospects of these surface modification methods were discussed. This review provides an important guidance or tool for developing surface functionalized PUs in the fields of bioengineering and medical devices.