Abstract：
OBJECTIVE: Monoamine neurotransmitters play a role in aggression, especially when altered by illicit substances. However, some literature suggests that not all illicit substances may lead to aggression, notably psychedelics. This narrative review investigates the associations between serotonergic psychedelics and MDMA on aggressive behaviour.
METHODS: PubMed and PsycINFO were searched for original, peer-reviewed articles evaluating the effects of serotonergic psychedelics and 3,4-methylenedioxymethamphetamine (MDMA) on violent and aggressive behavior using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
RESULTS: After removing duplicates, a total of 555 articles were screened, with 16 meeting the inclusion criteria. One additional article was obtained through reference screening bringing the total to 17 articles. Of these 17 articles, 14 studies focused on MDMA and three on serotonergic psychedelics. Findings were mixed, with some results demonstrating increased aggression following psychedelics and others suggesting protective effects. Limitations in the current literature include varied definitions of psychedelics, lack of standardized objective outcome measures, and failure to control for confounding.
CONCLUSIONS: As psychedelic research continues to expand, further assessment on the effects of serotonergic psychedelics and MDMA on aggressive behavior is required.
METHODS: PubMed and PsycINFO were searched for original, peer-reviewed articles evaluating the effects of serotonergic psychedelics and 3,4-methylenedioxymethamphetamine (MDMA) on violent and aggressive behavior using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
RESULTS: After removing duplicates, a total of 555 articles were screened, with 16 meeting the inclusion criteria. One additional article was obtained through reference screening bringing the total to 17 articles. Of these 17 articles, 14 studies focused on MDMA and three on serotonergic psychedelics. Findings were mixed, with some results demonstrating increased aggression following psychedelics and others suggesting protective effects. Limitations in the current literature include varied definitions of psychedelics, lack of standardized objective outcome measures, and failure to control for confounding.
CONCLUSIONS: As psychedelic research continues to expand, further assessment on the effects of serotonergic psychedelics and MDMA on aggressive behavior is required.
摘要：
目的：单胺类神经递质在攻击中发挥作用，特别是当被非法物质改变时。然而,一些文献表明，并非所有非法物质都可能导致侵略，尤其是迷幻药。这篇叙述性综述调查了5-羟色胺能迷幻药与MDMA对攻击行为的关联。
方法：搜索PubMed和PsycINFO的原件，同行评审的文章使用系统评价和荟萃分析(PRISMA)指南的首选报告项目,评估5-羟色胺能迷幻药和3,4-亚甲二氧基甲基苯丙胺(MDMA)对暴力和攻击行为的影响.
结果：删除重复项之后，共筛选了555篇文章，16人符合纳入标准。通过参考筛选获得了另一篇文章，使文章总数达到17篇。在这17篇文章中，14项研究集中在MDMA上，3项研究集中在5-羟色胺能迷幻药上。调查结果好坏参半,一些结果表明迷幻药后的攻击性增加，另一些则表明有保护作用。当前文献中的局限性包括迷幻药的各种定义，缺乏标准化的客观结果衡量标准，以及因混淆而无法控制。
结论：随着迷幻研究的不断扩大，需要进一步评估5-羟色胺能迷幻药和MDMA对攻击行为的影响.
方法：搜索PubMed和PsycINFO的原件，同行评审的文章使用系统评价和荟萃分析(PRISMA)指南的首选报告项目,评估5-羟色胺能迷幻药和3,4-亚甲二氧基甲基苯丙胺(MDMA)对暴力和攻击行为的影响.
结果：删除重复项之后，共筛选了555篇文章，16人符合纳入标准。通过参考筛选获得了另一篇文章，使文章总数达到17篇。在这17篇文章中，14项研究集中在MDMA上，3项研究集中在5-羟色胺能迷幻药上。调查结果好坏参半,一些结果表明迷幻药后的攻击性增加，另一些则表明有保护作用。当前文献中的局限性包括迷幻药的各种定义，缺乏标准化的客观结果衡量标准，以及因混淆而无法控制。
结论：随着迷幻研究的不断扩大，需要进一步评估5-羟色胺能迷幻药和MDMA对攻击行为的影响.
