PDF(Pubmed)
Abstract：
Ginseng is frequently used in traditional Chinese medicine to treat neurological disorders. The primary active component of ginseng is ginsenoside, which has been classified into more than 110 types based on their chemical structures. Ginsenoside Rb1 (GsRb1)-a protopanaxadiol saponin and a typical ginseng component-exhibits anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-autophagy properties in the nervous system. Neurological disorders remain a leading cause of death and disability globally. GsRb1 effectively treats neurological disorders. To contribute novel insights to the understanding and treatment of neurological disorders, we present a comprehensive review of the pharmacokinetics, actions, mechanisms, and research development of GsRb1 in neurological disorders.
摘要：
人参常用于中药治疗神经系统疾病。人参的主要活性成分是人参皂苷，根据其化学结构已分为110多种类型。人参皂苷Rb1（GsRb1）-一种原人参二醇皂苷和一种典型的人参成分-具有抗炎作用，抗氧化剂，抗凋亡，和神经系统的抗自噬特性。神经系统疾病仍然是全球死亡和残疾的主要原因。GsRb1有效治疗神经系统疾病。为神经系统疾病的理解和治疗提供新的见解，我们对药代动力学进行了全面的综述，行动,机制,以及GsRb1在神经系统疾病中的研究进展。
