PDF(Pubmed)
Abstract：
Personal care products (PCPs) contain a number of endocrine-disrupting chemicals (EDCs) that could potentially affect the reproductive function in women of childbearing age. However, studies focused on the effects of PCPs use on reproductive outcomes are very limited. The current study aimed to explore the relationships between PCPs use patterns and reproductive outcomes in women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment.
A total of 1500 women from the Tongji Reproductive and Environmental (TREE) study between December 2018 and January 2020 were included in this study. Participants provided characteristics of PCPs use within the previous three months. Retrieved oocyte number, mature oocyte number, two distinct pronuclei (2PN) zygote number, fertilization rate, cleavage rate, blastocyst formation rate, implantation, clinical pregnancy, miscarriage, and live birth were followed up as reproductive endpoints. Generalized linear regression model was utilized to assess the associations between various categories of PCPs use and reproductive endpoints of IVF/ICSI.
After adjusting for relevant covariates, women who used skin care products ≥14 times per week had a reduction of 22.4% in the maturation rate (95% CI: -39.2%, -1.6%) compared to participants who did not use skin care products. After transferring fresh embryos, women who used cosmetics 1-2 times per week (adjusted OR = 2.2, 95% CI: 1.0, 4.8) or 3-7 times per week (adjusted OR = 2.5, 95% CI: 1.2, 5.2) had a higher possibility of miscarriage than those who did not use cosmetics. There was negative association between the use of gel or soap and the cleavage rate among women aged < 30 years old (P for interaction = 0.01). Among women with BMI ≥ 24 kg/m2, the use of gel or soap was negatively associated with the blastocyst formation rate (P for interaction = 0.04), while cosmetics use was negatively associated with the maturation rate (P for interaction = 0.001).
Our findings suggest that the use of PCPs in women of reproductive age have a potential adverse impact on IVF/ICSI outcomes, particularly skin care and cosmetic products.
A total of 1500 women from the Tongji Reproductive and Environmental (TREE) study between December 2018 and January 2020 were included in this study. Participants provided characteristics of PCPs use within the previous three months. Retrieved oocyte number, mature oocyte number, two distinct pronuclei (2PN) zygote number, fertilization rate, cleavage rate, blastocyst formation rate, implantation, clinical pregnancy, miscarriage, and live birth were followed up as reproductive endpoints. Generalized linear regression model was utilized to assess the associations between various categories of PCPs use and reproductive endpoints of IVF/ICSI.
After adjusting for relevant covariates, women who used skin care products ≥14 times per week had a reduction of 22.4% in the maturation rate (95% CI: -39.2%, -1.6%) compared to participants who did not use skin care products. After transferring fresh embryos, women who used cosmetics 1-2 times per week (adjusted OR = 2.2, 95% CI: 1.0, 4.8) or 3-7 times per week (adjusted OR = 2.5, 95% CI: 1.2, 5.2) had a higher possibility of miscarriage than those who did not use cosmetics. There was negative association between the use of gel or soap and the cleavage rate among women aged < 30 years old (P for interaction = 0.01). Among women with BMI ≥ 24 kg/m2, the use of gel or soap was negatively associated with the blastocyst formation rate (P for interaction = 0.04), while cosmetics use was negatively associated with the maturation rate (P for interaction = 0.001).
Our findings suggest that the use of PCPs in women of reproductive age have a potential adverse impact on IVF/ICSI outcomes, particularly skin care and cosmetic products.
摘要：
■个人护理产品（PCPs）含有许多内分泌干扰化学物质（EDC），可能会影响育龄妇女的生殖功能。然而,关注PCP使用对生殖结局影响的研究非常有限。本研究旨在探讨接受体外受精/卵胞浆内单精子注射（IVF/ICSI）治疗的女性PCP使用模式与生殖结局之间的关系。
■2018年12月至2020年1月，共有1500名来自同济生殖与环境（TREE）研究的女性被纳入本研究。参与者提供了前三个月内PCP使用的特征。检索到的卵母细胞数，成熟卵母细胞数,两个不同的原核（2PN）合子数，受精率,卵裂率，囊胚形成率,植入,临床妊娠,流产,并将活产作为生殖终点进行随访。使用广义线性回归模型来评估各种类型的PCP使用与IVF/ICSI的生殖终点之间的关联。
■调整相关协变量后，每周使用护肤品≥14次的女性成熟率下降22.4%(95%CI:-39.2%,-1.6％）与未使用皮肤护理产品的参与者相比。转移新鲜胚胎后，每周使用化妆品1~2次(校正后OR=2.2,95%CI:1.0,4.8)或每周使用3~7次(校正后OR=2.5,95%CI:1.2,5.2)的女性流产的可能性高于不使用化妆品的女性.在年龄<30岁的女性中，凝胶或肥皂的使用与卵裂率之间呈负相关（P=0.01）。在BMI≥24kg/m2的女性中，凝胶或肥皂的使用与囊胚形成率呈负相关（相互作用的P=0.04），而化妆品的使用与成熟率呈负相关（相互作用的P=0.001）。
■我们的研究结果表明，在育龄妇女中使用PCP对IVF/ICSI结局有潜在的不利影响。特别是皮肤护理和化妆品。
■2018年12月至2020年1月，共有1500名来自同济生殖与环境（TREE）研究的女性被纳入本研究。参与者提供了前三个月内PCP使用的特征。检索到的卵母细胞数，成熟卵母细胞数,两个不同的原核（2PN）合子数，受精率,卵裂率，囊胚形成率,植入,临床妊娠,流产,并将活产作为生殖终点进行随访。使用广义线性回归模型来评估各种类型的PCP使用与IVF/ICSI的生殖终点之间的关联。
■调整相关协变量后，每周使用护肤品≥14次的女性成熟率下降22.4%(95%CI:-39.2%,-1.6％）与未使用皮肤护理产品的参与者相比。转移新鲜胚胎后，每周使用化妆品1~2次(校正后OR=2.2,95%CI:1.0,4.8)或每周使用3~7次(校正后OR=2.5,95%CI:1.2,5.2)的女性流产的可能性高于不使用化妆品的女性.在年龄<30岁的女性中，凝胶或肥皂的使用与卵裂率之间呈负相关（P=0.01）。在BMI≥24kg/m2的女性中，凝胶或肥皂的使用与囊胚形成率呈负相关（相互作用的P=0.04），而化妆品的使用与成熟率呈负相关（相互作用的P=0.001）。
■我们的研究结果表明，在育龄妇女中使用PCP对IVF/ICSI结局有潜在的不利影响。特别是皮肤护理和化妆品。
