Abstract：
Premature ovarian insufficiency (POI) refers to the decline of ovarian function before the age of 40. POI causes a reduction in or loss of female fertility, accompanied by different degrees of menopausal symptoms, which increases the risk of chronic diseases related to early menopause and seriously affects patients\' quality of life and health. It is conservatively estimated that at least one million prepubertal girls and women of reproductive age in China are at risk of iatrogenic POI caused by radiotherapy and chemotherapy every year. With the development of medical technology and the breakthrough of scientific and technological advances, preventing and treating iatrogenic POI have become possible. International and national guidelines consider cryopreserved ovarian tissue transplantation to be the most promising method of preserving the ovarian function and fertility of prepubertal girls and women of reproductive age who cannot delay radiotherapy and chemotherapy. In order to guide the clinical application of ovarian tissue cryopreservation and transplantation technology in China, the Guideline Working Group finally included 14 scientific questions and 18 recommendations through a questionnaire survey, field investigation, and consultation of a large number of Chinese and English literature databases in order to provide a reference for colleagues in clinical practice.
摘要：
过早卵巢功能不全（POI）是指40岁之前卵巢功能的下降。POI导致女性生育能力下降或丧失，伴有不同程度的更年期症状，这增加了与更年期提前相关的慢性病的风险，严重影响患者的生活质量和健康。保守估计,我国每年至少有100万青春期前少女和育龄妇女面临因放疗和化疗引起医源性POI的风险。随着医疗技术的发展和科技进步的突破,预防和治疗医源性POI已成为可能。国际和国家指南认为，冷冻保存的卵巢组织移植是最有希望的方法，可以保留不能延迟放疗和化疗的青春期前女孩和育龄妇女的卵巢功能和生育能力。为指导我国卵巢组织冷冻保存与移植技术的临床应用,准则工作组通过问卷调查最终纳入了14个科学问题和18个建议，实地调查,并查阅了大量的中英文文献数据库,以期为同行在临床实践中提供参考。
