PDF(Pubmed)
Abstract：
UNASSIGNED: Organophosphorus (OP) and carbamate poisoning are significant concerns in developing nations. This study evaluates the effectiveness of the ChE check mobile, a cholinesterase-rapid bedside diagnostic test, in the diagnosis and management of OP and carbamate poisoning.
UNASSIGNED: We conducted this prospective observational study, involving patients with OP and carbamate poisoning over 1 year (June 2016 to June 2017) at a single tertiary care center. Levels of RBC cholinesterase (E-AChE), butyl cholinesterase (BChE), and various other determinants were systematically coded and analyzed.
UNASSIGNED: The study population (n = 60) consisted primarily of males (n = 43; 71.7%), with a mean age of 30.6 (SD: 13.7) years. Monocrotophos (n = 10; 20.4%) and carbofuran (n = 4; 8.1%) were the commonest OP and carbamate compounds, respectively. The median initial atropinization dose was 10 (IQR: 0, 61.5) mg, with a median total administered atropine dose of 116 (IQR: 32, 320) mg. A significant negative correlation was found between E-AChE levels and both the initial atropinization dose (ρ: -0.653, p-value < 0.001) and total atropine requirement (ρ: -0.659, p-value < 0.001) during admission. An E-AChE cut-off of 4 units/g hemoglobin provided an area under the curve of 0.73 (sensitivity: 80.0%, specificity: 68.6%, p-value < 0.001) for predicting moderate to severe peradeniya organophosphorus poisoning.
UNASSIGNED: The check mobile device can be a valuable tool for prognosticating patients. There was a significant correlation between low E-AChE levels and the atropine requirement and severity.
UNASSIGNED: Jha A, Hazra D, Yadav B, Zachariah A, Alex R. Prognostication and Prediction of Outcomes in Patients with Organophosphorus and Carbamate Poisoning: A Prospective Cohort Study. Indian J Crit Care Med 2024;28(2):141-147.
UNASSIGNED: We conducted this prospective observational study, involving patients with OP and carbamate poisoning over 1 year (June 2016 to June 2017) at a single tertiary care center. Levels of RBC cholinesterase (E-AChE), butyl cholinesterase (BChE), and various other determinants were systematically coded and analyzed.
UNASSIGNED: The study population (n = 60) consisted primarily of males (n = 43; 71.7%), with a mean age of 30.6 (SD: 13.7) years. Monocrotophos (n = 10; 20.4%) and carbofuran (n = 4; 8.1%) were the commonest OP and carbamate compounds, respectively. The median initial atropinization dose was 10 (IQR: 0, 61.5) mg, with a median total administered atropine dose of 116 (IQR: 32, 320) mg. A significant negative correlation was found between E-AChE levels and both the initial atropinization dose (ρ: -0.653, p-value < 0.001) and total atropine requirement (ρ: -0.659, p-value < 0.001) during admission. An E-AChE cut-off of 4 units/g hemoglobin provided an area under the curve of 0.73 (sensitivity: 80.0%, specificity: 68.6%, p-value < 0.001) for predicting moderate to severe peradeniya organophosphorus poisoning.
UNASSIGNED: The check mobile device can be a valuable tool for prognosticating patients. There was a significant correlation between low E-AChE levels and the atropine requirement and severity.
UNASSIGNED: Jha A, Hazra D, Yadav B, Zachariah A, Alex R. Prognostication and Prediction of Outcomes in Patients with Organophosphorus and Carbamate Poisoning: A Prospective Cohort Study. Indian J Crit Care Med 2024;28(2):141-147.
摘要：
■有机磷（OP）和氨基甲酸酯中毒是发展中国家的重要问题。本研究评估了ChE检查手机的有效性，胆碱酯酶快速床边诊断测试，在OP和氨基甲酸酯中毒的诊断和管理中。
■我们进行了这项前瞻性观察研究，1年以上（2016年6月至2017年6月）的OP和氨基甲酸酯中毒患者在一个三级护理中心。RBC胆碱酯酶(E-AChE)水平,丁基胆碱酯酶(BChE),并对其他各种决定因素进行了系统编码和分析。
■研究人群（n=60）主要由男性组成（n=43；71.7％），平均年龄为30.6（SD：13.7）岁。久效磷(n=10;20.4%)和呋喃丹(n=4;8.1%)是最常见的OP和氨基甲酸酯化合物,分别。中位初始阿托品化剂量为10(IQR:0,61.5)mg，阿托品总给药剂量中位数为116(IQR：32,320)mg。入院期间E-AChE水平与初始阿托品化剂量（ρ：-0.653，p值<0.001）和总阿托品需求量（ρ：-0.659，p值<0.001）之间存在显着负相关。4单位/g血红蛋白的E-AChE截止值提供了0.73的曲线下面积（灵敏度：80.0％，特异性：68.6%，p值<0.001），用于预测中重度peradeniya有机磷中毒。
■检查移动设备可以成为预测患者的宝贵工具。低E-AChE水平与阿托品需求和严重程度之间存在显着相关性。
■JhaA,HazraD,YadavB,撒迦利亚A,有机磷和氨基甲酸酯中毒患者的预后和预后预测：一项前瞻性队列研究。印度J暴击护理中心2024；28（2）：141-147。
■我们进行了这项前瞻性观察研究，1年以上（2016年6月至2017年6月）的OP和氨基甲酸酯中毒患者在一个三级护理中心。RBC胆碱酯酶(E-AChE)水平,丁基胆碱酯酶(BChE),并对其他各种决定因素进行了系统编码和分析。
■研究人群（n=60）主要由男性组成（n=43；71.7％），平均年龄为30.6（SD：13.7）岁。久效磷(n=10;20.4%)和呋喃丹(n=4;8.1%)是最常见的OP和氨基甲酸酯化合物,分别。中位初始阿托品化剂量为10(IQR:0,61.5)mg，阿托品总给药剂量中位数为116(IQR：32,320)mg。入院期间E-AChE水平与初始阿托品化剂量（ρ：-0.653，p值<0.001）和总阿托品需求量（ρ：-0.659，p值<0.001）之间存在显着负相关。4单位/g血红蛋白的E-AChE截止值提供了0.73的曲线下面积（灵敏度：80.0％，特异性：68.6%，p值<0.001），用于预测中重度peradeniya有机磷中毒。
■检查移动设备可以成为预测患者的宝贵工具。低E-AChE水平与阿托品需求和严重程度之间存在显着相关性。
■JhaA,HazraD,YadavB,撒迦利亚A,有机磷和氨基甲酸酯中毒患者的预后和预后预测：一项前瞻性队列研究。印度J暴击护理中心2024；28（2）：141-147。
