PDF(Pubmed)
Abstract：
UNASSIGNED: Metabolic associated fatty liver disease (MAFLD) is a novel terminology introduced in 2020 to provide a more accurate description of fatty liver disease associated with metabolic dysfunction. It replaces the outdated term nonalcoholic fatty liver disease (NAFLD) and aims to improve diagnostic criteria and tailored treatment strategies for the disease. NAFLD, the most prevalent liver disease in western industrialized nations, has been steadily increasing in prevalence and is associated with serious complications such as cirrhosis and hepatocellular carcinoma. It is also linked to insulin resistance syndrome and cardiovascular diseases. However, current studies on NAFLD have limitations in meeting necessary histological endpoints.
UNASSIGNED: This literature review aims to consolidate recent knowledge and discoveries concerning MAFLD, integrating the diverse aspects of the disease. Specifically, it focuses on analyzing the diagnostic criteria for MAFLD, differentiating it from NAFLD and alcoholic fatty liver disease (AFLD), and exploring the epidemiology, clinical manifestations, pathogenesis, and management approaches associated with MAFLD. The review also explores the associations between MAFLD and other conditions. It discusses the heightened mortality risk associated with MAFLD and its link to chronic kidney disease (CKD), showing that MAFLD exhibits enhanced diagnostic accuracy for identifying patients with CKD compared to NAFLD. The association between MAFLD and incident/prevalent CKD is supported by cohort studies and meta-analyses.
UNASSIGNED: This literature review highlights the importance of MAFLD as a distinct terminology for fatty liver disease associated with metabolic dysfunction. The review provides insights into the diagnostic criteria, associations with CKD, and management approaches for MAFLD. Further research is needed to develop more accurate diagnostic tools for advanced fibrosis in MAFLD and to explore the underlying mechanisms linking MAFLD with other conditions. This review serves as a valuable resource for researchers and healthcare professionals seeking a comprehensive understanding of MAFLD.
UNASSIGNED: This literature review aims to consolidate recent knowledge and discoveries concerning MAFLD, integrating the diverse aspects of the disease. Specifically, it focuses on analyzing the diagnostic criteria for MAFLD, differentiating it from NAFLD and alcoholic fatty liver disease (AFLD), and exploring the epidemiology, clinical manifestations, pathogenesis, and management approaches associated with MAFLD. The review also explores the associations between MAFLD and other conditions. It discusses the heightened mortality risk associated with MAFLD and its link to chronic kidney disease (CKD), showing that MAFLD exhibits enhanced diagnostic accuracy for identifying patients with CKD compared to NAFLD. The association between MAFLD and incident/prevalent CKD is supported by cohort studies and meta-analyses.
UNASSIGNED: This literature review highlights the importance of MAFLD as a distinct terminology for fatty liver disease associated with metabolic dysfunction. The review provides insights into the diagnostic criteria, associations with CKD, and management approaches for MAFLD. Further research is needed to develop more accurate diagnostic tools for advanced fibrosis in MAFLD and to explore the underlying mechanisms linking MAFLD with other conditions. This review serves as a valuable resource for researchers and healthcare professionals seeking a comprehensive understanding of MAFLD.
摘要：
■代谢相关的脂肪肝疾病（MAFLD）是2020年引入的新术语，旨在更准确地描述与代谢功能障碍相关的脂肪肝疾病。它取代了过时的术语非酒精性脂肪性肝病（NAFLD），旨在改善该疾病的诊断标准和量身定制的治疗策略。NAFLD,西方工业化国家最普遍的肝病，患病率一直稳步上升，并与肝硬化和肝细胞癌等严重并发症有关。它还与胰岛素抵抗综合征和心血管疾病有关。然而,目前对NAFLD的研究在满足必要的组织学终点方面存在局限性.
■本文献综述旨在巩固有关MAFLD的最新知识和发现，整合疾病的各个方面。具体来说,它侧重于分析MAFLD的诊断标准，将其与NAFLD和酒精性脂肪性肝病（AFLD）区分开来，探索流行病学，临床表现，发病机制，以及与MAFLD相关的管理方法。该评论还探讨了MAFLD与其他条件之间的关联。它讨论了与MAFLD相关的死亡风险增加及其与慢性肾脏疾病（CKD）的联系，与NAFLD相比，MAFLD在识别CKD患者方面表现出更高的诊断准确性。队列研究和荟萃分析支持MAFLD与事件/流行CKD之间的关联。
■这篇文献综述强调了MAFLD作为与代谢功能障碍相关的脂肪肝疾病的独特术语的重要性。该评论提供了对诊断标准的见解，与CKD的关联，以及MAFLD的管理方法。需要进一步的研究来开发更准确的MAFLD晚期纤维化诊断工具，并探索MAFLD与其他疾病的潜在机制。这篇综述为寻求全面了解MAFLD的研究人员和医疗保健专业人员提供了宝贵的资源。
■本文献综述旨在巩固有关MAFLD的最新知识和发现，整合疾病的各个方面。具体来说,它侧重于分析MAFLD的诊断标准，将其与NAFLD和酒精性脂肪性肝病（AFLD）区分开来，探索流行病学，临床表现，发病机制，以及与MAFLD相关的管理方法。该评论还探讨了MAFLD与其他条件之间的关联。它讨论了与MAFLD相关的死亡风险增加及其与慢性肾脏疾病（CKD）的联系，与NAFLD相比，MAFLD在识别CKD患者方面表现出更高的诊断准确性。队列研究和荟萃分析支持MAFLD与事件/流行CKD之间的关联。
■这篇文献综述强调了MAFLD作为与代谢功能障碍相关的脂肪肝疾病的独特术语的重要性。该评论提供了对诊断标准的见解，与CKD的关联，以及MAFLD的管理方法。需要进一步的研究来开发更准确的MAFLD晚期纤维化诊断工具，并探索MAFLD与其他疾病的潜在机制。这篇综述为寻求全面了解MAFLD的研究人员和医疗保健专业人员提供了宝贵的资源。
