PDF(Pubmed)
Abstract：
UNASSIGNED: Lumbar spinal fusion surgery is a well-established treatment for various spinal disorders. However, one of its complications, pseudoarthrosis, poses a significant concern. This study aims to explore the incidence, time and predictive factors contributing to pseudoarthrosis in patients who have undergone lumbar fusion surgery over a 10-year period.
UNASSIGNED: Data for this research was sourced from the PearlDiver database where insurance claims of patients who underwent multilevel lumbar spinal fusion between 01/01/2010 and 10/31/2022 were examined for claims of pseudoarthrosis within the 10 years of their index procedure. A variety of demographic, comorbid, and surgical factors were assessed, including age, gender, Elixhauser Comorbidity Index (ECI), surgical approach, substance use disorders and history of spinal disorders. Statistical analyses, including chi-squared tests, multivariate analysis, and cox survival analysis were employed to determine significant associations.
UNASSIGNED: Among the 76,337 patients included in this retrospective study, 2.70% were diagnosed with symptomatic lumbar pseudoarthrosis at an average of 7.38 years in a 10-year follow-up. Multivariate and Cox hazard analyses revealed that significant predictors of symptomatic pseudoarthrosis development following multilevel primary lumbar fusion include vitamin D deficiency, osteoarthritis, opioid and NSAID use, tobacco use, and a prior history of congenital spine disorders.
UNASSIGNED: In summary, this study revealed a 2.70% incidence of symptomatic lumbar pseudoarthrosis within 10 years of the index procedure. It highlighted several potential predictive factors, including comorbidities, surgical approaches, and substance use disorders, associated with the development of symptomatic pseudoarthrosis. Future research should focus on refining our understanding of these factors to improve patient outcomes and optimize healthcare resource allocation.
UNASSIGNED: Data for this research was sourced from the PearlDiver database where insurance claims of patients who underwent multilevel lumbar spinal fusion between 01/01/2010 and 10/31/2022 were examined for claims of pseudoarthrosis within the 10 years of their index procedure. A variety of demographic, comorbid, and surgical factors were assessed, including age, gender, Elixhauser Comorbidity Index (ECI), surgical approach, substance use disorders and history of spinal disorders. Statistical analyses, including chi-squared tests, multivariate analysis, and cox survival analysis were employed to determine significant associations.
UNASSIGNED: Among the 76,337 patients included in this retrospective study, 2.70% were diagnosed with symptomatic lumbar pseudoarthrosis at an average of 7.38 years in a 10-year follow-up. Multivariate and Cox hazard analyses revealed that significant predictors of symptomatic pseudoarthrosis development following multilevel primary lumbar fusion include vitamin D deficiency, osteoarthritis, opioid and NSAID use, tobacco use, and a prior history of congenital spine disorders.
UNASSIGNED: In summary, this study revealed a 2.70% incidence of symptomatic lumbar pseudoarthrosis within 10 years of the index procedure. It highlighted several potential predictive factors, including comorbidities, surgical approaches, and substance use disorders, associated with the development of symptomatic pseudoarthrosis. Future research should focus on refining our understanding of these factors to improve patient outcomes and optimize healthcare resource allocation.
摘要：
■腰椎融合术是各种脊柱疾病的公认治疗方法。然而,它的并发症之一，假关节炎,引起了极大的关注。本研究旨在探讨发病率,在10年时间内接受腰椎融合术的患者中,导致假关节炎的时间和预测因素.
■本研究的数据来自PearlDiver数据库，在该数据库中，对2010年1月1日至2022年10月31日期间接受多层腰椎融合术的患者的保险索赔进行了检查，以确定其索引程序的10年内假性关节病的索赔。各种各样的人口，共病，和手术因素进行了评估，包括年龄,性别,Elixhauser合并症指数（ECI），手术方法,物质使用障碍和脊柱疾病史。统计分析，包括卡方检验，多变量分析，和cox生存分析用于确定显著关联。
■在这项回顾性研究中纳入的76,337名患者中，在10年的随访中，平均7.38年，2.70％的患者被诊断为症状性腰椎假性关节炎。多变量和Cox风险分析显示，多水平原发性腰椎融合术后症状性假性关节炎发展的重要预测因素包括维生素D缺乏，骨关节炎,阿片类药物和NSAID的使用，烟草使用,和先天性脊柱疾病的既往史。
■总之，这项研究显示，在索引程序的10年内，有症状的腰椎假性关节病的发生率为2.70％。它强调了几个潜在的预测因素，包括合并症,手术方法,和物质使用障碍，与症状性假性关节炎的发展有关。未来的研究应该集中在完善我们对这些因素的理解上，以改善患者的预后并优化医疗资源分配。
■本研究的数据来自PearlDiver数据库，在该数据库中，对2010年1月1日至2022年10月31日期间接受多层腰椎融合术的患者的保险索赔进行了检查，以确定其索引程序的10年内假性关节病的索赔。各种各样的人口，共病，和手术因素进行了评估，包括年龄,性别,Elixhauser合并症指数（ECI），手术方法,物质使用障碍和脊柱疾病史。统计分析，包括卡方检验，多变量分析，和cox生存分析用于确定显著关联。
■在这项回顾性研究中纳入的76,337名患者中，在10年的随访中，平均7.38年，2.70％的患者被诊断为症状性腰椎假性关节炎。多变量和Cox风险分析显示，多水平原发性腰椎融合术后症状性假性关节炎发展的重要预测因素包括维生素D缺乏，骨关节炎,阿片类药物和NSAID的使用，烟草使用,和先天性脊柱疾病的既往史。
■总之，这项研究显示，在索引程序的10年内，有症状的腰椎假性关节病的发生率为2.70％。它强调了几个潜在的预测因素，包括合并症,手术方法,和物质使用障碍，与症状性假性关节炎的发展有关。未来的研究应该集中在完善我们对这些因素的理解上，以改善患者的预后并优化医疗资源分配。
