PDF(Pubmed)
Abstract：
The objective of this study was to compare celecoxib, diclofenac, and ibuprofen for managing postoperative pain, swelling, and trismus after a third molar extraction. There were 90 patients included and randomly allocated, 30 in each of the three study groups. The primary outcome of this trial was postoperative pain, and the secondary outcomes were postoperative swelling and trismus. The celecoxib and diclofenac groups showed better postoperative pain control compared to ibuprofen. Moreover, diclofenac showed better pain control compared to both celecoxib and ibuprofen within the first 72 hours postoperatively: one hour (p=0.005), six hours (p=0.001), 12 hours (p=0.044 ), 24 hours (p=0.017), 48 hours (p=0.006), and 72 hours (p=0.012 ). Regarding the secondary outcomes, there was no statistical difference in the swelling and trismus measurements during the postoperative period between the three study groups. The results of this study showed that celecoxib pain management post-third molar extraction is comparable to that of diclofenac and superior to that of ibuprofen.
摘要：
这项研究的目的是比较塞来昔布，双氯芬酸,和布洛芬用于治疗术后疼痛，肿胀,和第三磨牙拔除后的三嘴。有90名患者被纳入并随机分配，三个研究组各30。这项试验的主要结果是术后疼痛，次要结局是术后肿胀和三联肌.与布洛芬相比，塞来昔布和双氯芬酸组显示出更好的术后疼痛控制。此外，与塞来昔布和布洛芬相比，双氯芬酸在术后前72小时内显示出更好的疼痛控制：1小时（p=0.005），6小时（p=0.001），12小时（p=0.044），24小时（p=0.017），48小时（p=0.006），和72小时(p=0.012)。关于次要结果，3个研究组在术后期间的肿胀和张口测量值无统计学差异.这项研究的结果表明，第三磨牙拔除后的塞来昔布疼痛管理与双氯芬酸相当，优于布洛芬。
