PDF(Pubmed)
Abstract：
The long-term effects of SARS-CoV-2 infection represent a relevant global health problem. Long COVID (LC) is defined as a complex of signs and symptoms developed during or after SARS-CoV-2 infection and lasting > 12 weeks. In common variable immunodeficiency (CVID) patients, we previously reported higher risk of hospitalization and death during SARS-CoV-2 infection, as well as prolonged swab positivity and frequent reinfections. The aim of the present study was to assess the risk of LC in an Italian cohort of CVID patients. We used a translated version of the survey proposed by Centers for Disease Control and Prevention (CDC) to collect data on LC. In the enrolled cohort of 175 CVID patients, we found a high prevalence of LC (65.7%). The most frequent LC symptoms were fatigue (75.7%), arthralgia/myalgia (48.7%), and dyspnea (41.7%). The majority of patients (60%) experienced prolonged symptoms, for at least 6 months after infection. In a multivariate analysis, the presence of complicated phenotype (OR 2.44, 95% CI 1.88-5.03; p = 0.015), obesity (OR 11.17, 95% CI 1.37-90.95; p = 0.024), and female sex (OR 2.06, 95% CI 1.09-3.89; p = 0.024) significantly correlated with the development of LC. In conclusion, in this multicenter observational cohort study, we demonstrated that CVID patients present an increased prevalence of LC when compared to the general population. Improved awareness on the risk of LC in CVID patients could optimize management of this new and alarming complication of SARS-CoV-2 infection.
摘要：
SARS-CoV-2感染的长期影响代表了相关的全球健康问题。长COVID（LC）定义为SARS-CoV-2感染期间或之后出现的症状和体征的复合物，持续时间超过12周。在常见的可变免疫缺陷（CVID）患者中，我们以前报道过SARS-CoV-2感染期间住院和死亡的风险更高，以及长期的拭子阳性和频繁的再感染。本研究的目的是评估意大利CVID患者队列中LC的风险。我们使用疾病控制和预防中心（CDC）提出的调查的翻译版本来收集有关LC的数据。在175名CVID患者的队列中，我们发现LC的患病率很高(65.7%).最常见的LC症状是疲劳（75.7%），关节痛/肌痛（48.7%），和呼吸困难（41.7%）。大多数患者（60％）经历了长时间的症状，感染后至少6个月。在多变量分析中，复杂表型的存在（OR2.44，95％CI1.88-5.03；p=0.015），肥胖（OR11.17，95%CI1.37-90.95；p=0.024），和女性性别（OR2.06，95％CI1.09-3.89；p=0.024）与LC的发展显着相关。总之,在这项多中心观察队列研究中，我们证明,与普通人群相比,CVID患者的LC患病率增加.提高对CVID患者LC风险的认识可以优化对SARS-CoV-2感染这种新的令人担忧的并发症的管理。
