PDF(Pubmed)
Abstract：
Ulcer disorders including the oral mucosa, large intestine, and stomach mucosa, cause significant global health burdens. Conventional treatments such as non-steroid anti-inflammatory drugs (NSAIDs), proton pump inhibitors (PPIs), histamine H2 receptor antagonists (H2RAs), and cytoprotective agents have drawbacks like mucosal injury, diminish gastric acid secretion, and interact with concurrent medications. Therefore, alternative therapeutic approaches are needed to tackle this health concern. Plants are rich in active metabolites in the bark, roots, leaves, fruits, and seeds, and have been utilized for medicinal purposes since ancient times. The use of herbal therapy is crucial, and regulations are necessary to ensure the quality of products, particularly in randomized studies, to assess their efficacy and safety in treating ulcer disorders. This study aims to explore the anti-ulcer activity of medicinal plants in treating peptic ulcer disease, ulcerative colitis, and aphthous ulcers. Articles were searched in Scopus and PubMed, and filtered for publication from 2013 to 2023, resulting in a total of 460 from Scopus and 239 from PubMed. The articles were further screened by title and abstract and resulted in 55 articles. Natural products, rich in active metabolites, were described to manage ulcer disease by protecting the mucosa, reducing ulcer effects, inhibiting pro-inflammatory factors, and reducing bacterial load, thus improving patients\' quality of life. Natural extracts have proven effective in managing other health problems, including ulcers by reducing pain and decreasing lesions. This review provides an overview of preclinical and clinical studies on medicinal plants, focusing on their effectiveness in treating conditions like peptic ulcers, ulcerative colitis, and aphthous ulcers.
摘要：
包括口腔粘膜在内的溃疡疾病，大肠,和胃粘膜，造成重大的全球健康负担。常规治疗，如非类固醇抗炎药（NSAIDs），质子泵抑制剂（PPI），组胺H2受体拮抗剂（H2RAs），细胞保护剂有粘膜损伤等缺点，减少胃酸分泌，并与并发药物相互作用。因此,需要替代治疗方法来解决这一健康问题。植物在树皮中富含活性代谢物，根,叶子,水果,和种子，自古以来就被用于医疗目的。使用草药疗法至关重要，和法规对于确保产品质量是必要的，特别是在随机研究中，评估其治疗溃疡的有效性和安全性。本研究旨在探索药用植物治疗消化性溃疡的抗溃疡活性,溃疡性结肠炎,和口疮溃疡。文章在Scopus和PubMed中搜索，并在2013年至2023年进行了过滤以供发布，导致Scopus的总数为460，PubMed的总数为239。根据标题和摘要对文章进行了进一步筛选，得出55篇文章。天然产品,富含活性代谢物，被描述为通过保护粘膜来管理溃疡疾病，减少溃疡的影响，抑制促炎因子，减少细菌负荷，从而提高患者的生活质量。天然提取物已被证明有效管理其他健康问题，包括通过减少疼痛和减少病变的溃疡。这篇综述概述了药用植物的临床前和临床研究，专注于它们治疗消化性溃疡等疾病的有效性，溃疡性结肠炎,和口疮溃疡。
