PDF(Pubmed)
Abstract：
UNASSIGNED: Previous studies have reported alterations in brain structure in major depressive disorder (MDD) patients with suicide attempts. However, age-related changes in suicidal MDD patients remain unclear.
UNASSIGNED: We performed a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Embase, PubMed, and Web of Science were searched to identify relevant studies from inception to January 2023. All voxel-based and surface-based morphometry studies comparing suicidal MDD patients to MDD or healthy controls were included. Studies were then grouped by age range (old, middle-age, adolescent) and the commonalities and age-related structural brain alterations were summarized. The included studies were evaluated using the Newcastle-Ottawa Scale (NOS).
UNASSIGNED: A total of 17 studies met the inclusion criteria, including 3 of late-life depression (LLD) patients, 11 of middle-aged depression (MAD) patients, and 3 of adolescent depression (AOD) patients. The majority of studies had moderate to high NOS scores, indicating good quality. Patients in all three age groups exhibited extensive alterations in the lateral, medial, and orbital regions of the frontal lobes. Furthermore, suicidal MAD patients showed a specific decrease in the gray matter volume of the dorsolateral prefrontal cortex compared to suicidal LLD patients. Cortical thickness and left angular gyrus volume were decreased in suicidal MAD and suicidal LLD patients, but increased in suicidal AOD patients.
UNASSIGNED: This systematic review summarizes structural brain changes in suicidal MDD patients at three age groups: elderly, middle-aged, and adolescent. These findings help elucidate the common circuitry of MDD related to suicide over the lifespan and highlight unique circuitry associated with different ages. These findings may help predict the risk of suicide in MDD patients at different ages.
UNASSIGNED: We performed a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Embase, PubMed, and Web of Science were searched to identify relevant studies from inception to January 2023. All voxel-based and surface-based morphometry studies comparing suicidal MDD patients to MDD or healthy controls were included. Studies were then grouped by age range (old, middle-age, adolescent) and the commonalities and age-related structural brain alterations were summarized. The included studies were evaluated using the Newcastle-Ottawa Scale (NOS).
UNASSIGNED: A total of 17 studies met the inclusion criteria, including 3 of late-life depression (LLD) patients, 11 of middle-aged depression (MAD) patients, and 3 of adolescent depression (AOD) patients. The majority of studies had moderate to high NOS scores, indicating good quality. Patients in all three age groups exhibited extensive alterations in the lateral, medial, and orbital regions of the frontal lobes. Furthermore, suicidal MAD patients showed a specific decrease in the gray matter volume of the dorsolateral prefrontal cortex compared to suicidal LLD patients. Cortical thickness and left angular gyrus volume were decreased in suicidal MAD and suicidal LLD patients, but increased in suicidal AOD patients.
UNASSIGNED: This systematic review summarizes structural brain changes in suicidal MDD patients at three age groups: elderly, middle-aged, and adolescent. These findings help elucidate the common circuitry of MDD related to suicide over the lifespan and highlight unique circuitry associated with different ages. These findings may help predict the risk of suicide in MDD patients at different ages.
摘要：
■先前的研究报道了重度抑郁症（MDD）患者自杀未遂时大脑结构的改变。然而,自杀性MDD患者的年龄相关变化尚不清楚.
■我们遵循系统评价和荟萃分析（PRISMA）指南的首选报告项目进行了系统评价。Embase,PubMed,和WebofScience进行了搜索，以确定从开始到2023年1月的相关研究。包括所有基于体素和基于表面的形态计量学研究，将自杀性MDD患者与MDD或健康对照进行比较。然后按年龄范围对研究进行分组(老年，中年,青少年），并总结了与年龄相关的大脑结构改变。采用纽卡斯尔-渥太华量表(NOS)对纳入的研究进行评价。
■共有17项研究符合纳入标准，包括3名晚期抑郁症（LLD）患者，11的中年抑郁症（MAD）患者，和3名青少年抑郁症(AOD)患者。大多数研究有中等到高的NOS分数，表明质量好。所有三个年龄组的患者都表现出外侧的广泛改变，中间,和额叶的轨道区域。此外，与自杀LLD患者相比，自杀MAD患者的背外侧前额叶皮质灰质体积明显减少。自杀性MAD和自杀性LLD患者的皮质厚度和左角回体积减少，但在自杀AOD患者中增加。
■本系统综述总结了三个年龄组的自杀性MDD患者的大脑结构变化：老年人，中年,和青少年。这些发现有助于阐明MDD在整个生命周期中与自杀相关的常见电路，并强调与不同年龄相关的独特电路。这些发现可能有助于预测不同年龄MDD患者的自杀风险。
■我们遵循系统评价和荟萃分析（PRISMA）指南的首选报告项目进行了系统评价。Embase,PubMed,和WebofScience进行了搜索，以确定从开始到2023年1月的相关研究。包括所有基于体素和基于表面的形态计量学研究，将自杀性MDD患者与MDD或健康对照进行比较。然后按年龄范围对研究进行分组(老年，中年,青少年），并总结了与年龄相关的大脑结构改变。采用纽卡斯尔-渥太华量表(NOS)对纳入的研究进行评价。
■共有17项研究符合纳入标准，包括3名晚期抑郁症（LLD）患者，11的中年抑郁症（MAD）患者，和3名青少年抑郁症(AOD)患者。大多数研究有中等到高的NOS分数，表明质量好。所有三个年龄组的患者都表现出外侧的广泛改变，中间,和额叶的轨道区域。此外，与自杀LLD患者相比，自杀MAD患者的背外侧前额叶皮质灰质体积明显减少。自杀性MAD和自杀性LLD患者的皮质厚度和左角回体积减少，但在自杀AOD患者中增加。
■本系统综述总结了三个年龄组的自杀性MDD患者的大脑结构变化：老年人，中年,和青少年。这些发现有助于阐明MDD在整个生命周期中与自杀相关的常见电路，并强调与不同年龄相关的独特电路。这些发现可能有助于预测不同年龄MDD患者的自杀风险。
