METHODS: The study included 409 women who had undergone breast cancer surgery at least 1 year before enrollment. A generalized linear model was used to estimate the least square means and 95% confidence intervals of plasma levels of inflammatory markers according to lifestyle factors defined in terms of adherence to the ACS guidelines.
RESULTS: Higher overall adherence scores were associated with lower levels of high-sensitivity C-reactive protein (hs-CRP) (p for trend=0.015) and higher levels of adiponectin (p for trend=0.009). Similar significant associations of hs-CRP (p for trend= 0.004) and adiponectin (p for trend=0.010) levels were observed with the score for the body mass index (BMI) component of the adherence score. A higher diet component score was associated with a higher adiponectin level (p for trend=0.020), but there was no significant association for the physical activity component score.
CONCLUSIONS: The present study\'s findings suggest that maintaining a healthy lifestyle according to the ACS guidelines was associated with beneficial effects on inflammatory marker levels, especially hs-CRP and adiponectin, among breast cancer survivors. Among the 3 components of lifestyle guidelines, the BMI component exhibited the most similar tendency to the overall adherence score in relation to inflammatory indicators. Further prospective and intervention studies are needed to investigate longitudinal associations between lifestyle factors and inflammatory markers among breast cancer survivors.
该研究包括409名在入组前至少1年接受过乳腺癌手术的女性。根据根据对ACS指南的依从性定义的生活方式因素,使用广义线性模型来估计炎症标志物血浆水平的最小二乘均值和95%置信区间。
■较高的总依从性评分与较低的高敏C反应蛋白(hs-CRP)水平(趋势p=0.0153)和较高的脂联素水平(趋势p=0.0095)相关。观察到hs-CRP(趋势p=0.0040)和脂联素(趋势p=0.0097)水平与依从性评分的体重指数(BMI)评分相似的显着关联。较高的饮食成分评分与较高的脂联素水平相关(趋势p=0.0198),但与体力活动分量评分没有显著关联.
■本研究的研究结果表明,根据ACS指南保持健康的生活方式与对炎症标志物水平的有益影响有关,尤其是hs-CRP和脂联素,在乳腺癌幸存者中。在生活方式指南的三个组成部分中,在炎症指标方面,BMI分量与总体依从性评分呈现最相似的趋势.需要进一步的前瞻性和干预研究来调查乳腺癌幸存者中生活方式因素和炎症标志物之间的纵向关联。